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Guaifenesin / Pseudoephedrine Dosage

Applies to the following strength(s): 400 mg-60 mg ; 600 mg-120 mg ; 200 mg-30 mg ; 100 mg-30 mg/5 mL ; 50 mg-15 mg/5 mL ; 50 mg-15 mg ; 400 mg-120 mg ; 600 mg-60 mg ; 250 mg-120 mg ; 300 mg-60 mg ; 1200 mg-120 mg ; 125 mg-60 mg ; 200 mg-60 mg ; 500 mg-120 mg ; 100 mg-60 mg ; 250 mg-30 mg ; 800 mg-80 mg ; 600 mg-45 mg ; 595 mg-48 mg ; 200 mg-45 mg/5 mL ; 600 mg-90 mg ; 795 mg-85 mg ; 200 mg-40 mg/5 mL ; 1200 mg-60 mg ; 1200 mg-90 mg ; 500 mg-60 mg ; 800 mg-90 mg ; 1200 mg-50 mg ; 800 mg-120 mg ; 250 mg-90 mg ; 150 mg-30 mg ; 800 mg-60 mg ; 380 mg-60 mg ; 650 mg-90 mg ; 400 mg-45 mg ; 650 mg-45 mg ; 50 mg-7.5 mg/mL ; 400 mg-90 mg ; 400 mg-40 mg ; 400 mg-30 mg ; 400 mg-20 mg ; 550 mg-60 mg ; 700 mg-80 mg ; 580 mg-60 mg ; 780 mg-80 mg ; 525 mg-50 mg ; 525 mg-120 mg ; 800 mg-45 mg ; 1200 mg-75 mg ; 1000 mg-60 mg ; 375 mg-60 mg

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Cough and Nasal Congestion

Immediate release tablets: 1 tablet (30 mg to 45 mg pseudoephedrine) orally up to 4 times a day.
Immediate release syrup: 10 mL (30 mg to 90 mg pseudoephedrine) orally up to 4 times a day.
Immediate release capsule: 1 or 2 capsules (30 mg to 60 mg pseudoephedrine) every 4 to 6 hours, not to exceed 4 capsules in 24 hours.
Extended release tablets or capsules: 1 tablet or capsule (30 mg to 120 mg pseudoephedrine) orally every 12 hours.

Maximum is 240 mg pseudoephedrine or 2.4 g of guaifenesin/day.

Usual Pediatric Dose for Cough and Nasal Congestion

3 years or older:
Immediate release tablet, capsule or syrup (15 mg to 60 mg pseudoephedrine) orally up to every 4 hours, not to exceed 4 mg/kg pseudoephedrine HCl or 12 mg/kg of guaifenesin/day.

guaifenesin-pseudoephedrine 50 mg-7.5 mg/mL pediatric drops:
2 years to under 6 years (11 to 21 kg): 2 mL every 4 to 6 hours, not to exceed 4 doses in 24 hours.

13 years or older:
1 extended release tablet or capsule (30 mg to 120 mg pseudoephedrine) every 12 hours, not to exceed 4 mg/kg pseudoephedrine HCl or 12 mg/kg of guaifenesin/day.

guaifenesin-pseudoephedrine 150 mg-30 mg oral capsule:
12 years or older: 1 or 2 capsules every 4 to 6 hours, not to exceed 8 capsules in 24 hours.
6 years to 11 years: 1 capsule every 4 to 6 hours, not to exceed 4 capsules in 24 hours.

Renal Dose Adjustments

Pseudoephedrine is eliminated by the kidney and may accumulate in patients with renal dysfunction. Patients with renal dysfunction should be monitored for signs and symptoms of toxicity when using pseudoephedrine.

Liver Dose Adjustments

Data not available

Precautions

The FDA has not approved use of over-the-counter cough and cold medications to children aged less than 2 years, and proper dosing for children in this age group has not been studied. Clinicians should be aware of the risk for serious illness or fatal overdose from administration of cough and cold medications to children aged less than 2 years. Clinicians should be certain that caregivers understand 1) the importance of administering cough and cold medications only as directed and 2) the risk for overdose if they administer additional medications that might contain the same ingredient.

Dialysis

Pseudoephedrine is partially removed by hemodialysis, therefore doses should be given following dialysis sessions.

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