Emcyt Side Effects

Generic Name: estramustine

Note: This page contains information about the side effects of estramustine. Some of the dosage forms included on this document may not apply to the brand name Emcyt.

Not all side effects for Emcyt may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to estramustine: oral capsule

Along with its needed effects, estramustine (the active ingredient contained in Emcyt) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking estramustine:

  • Black, tarry stools
  • blood in urine or stools
  • cough or hoarseness
  • fever or chills
  • headaches (severe or sudden)
  • loss of coordination (sudden)
  • lower back or side pain
  • painful or difficult urination
  • pains in chest, groin, or leg (especially calf of leg)
  • pinpoint red spots on skin
  • shortness of breath (sudden, for no apparent reason)
  • slurred speech (sudden)
  • unusual bleeding or bruising
  • vision changes (sudden)
  • weakness or numbness in arm or leg

Check with your doctor as soon as possible if any of the following side effects occur while taking estramustine:

More common
  • Swelling of feet or lower legs
  • Skin rash or fever
  • unusual tiredness or weakness

Some side effects of estramustine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Breast tenderness or enlargement
  • decreased interest in sex
  • diarrhea
  • nausea
Less common
  • Trouble in sleeping
  • vomiting

For Healthcare Professionals

Applies to estramustine: oral capsule


Gynecomastia and impotence have been reported as estrogenic effects.

Genitourinary side effects including breast tenderness (71%), mild breast enlargement (65%), and moderate breast enlargement (11%) have been reported. One case of hemolytic-uremic syndrome has also been reported.


Hepatic side effects including LDH and/or SGOT abnormalities (33%), bilirubin and SGOT abnormalities (2%), and bilirubin, LDH, and SGOT abnormalities (2%) have been reported.


Exacerbation of preexisting or incipient peripheral edema or congestive heart disease has been reported.

Cardiovascular side effects including edema (20%), leg cramps (9%), myocardial infarction (3%), thrombophlebitis (3%), congestive heart failure (3%), cerebrovascular accident (2%), and pulmonary emboli (2%) have been reported.


Gastrointestinal side effects including nausea (16%), diarrhea (13%), minor gastrointestinal upset (11%), anorexia (4%), and flatulence (2%) have been reported.


Respiratory side effects including dyspnea (12%) have been reported.


Hematologic side effects including leukopenia (4%) have been reported.


Other side effects including lethargy (4%), insomnia (3%), and emotional lability (2%) have been reported.


Dermatologic side effects including easy bruising (3%), pruritus (2%), and dry skin (2%) have been reported.


Oncologic side effects including mutagenicity have been reported for both estradiol and nitrogen mustard. Animal studies on estrogens have reported an increase in the frequency of carcinomas of the breast and liver.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.