Denavir Side Effects

Generic Name: penciclovir topical

Note: This page contains information about the side effects of penciclovir topical. Some of the dosage forms included on this document may not apply to the brand name Denavir.

Not all side effects for Denavir may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to penciclovir topical: topical cream

Along with its needed effects, penciclovir topical (the active ingredient contained in Denavir) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking penciclovir topical:

  • Mild pain, burning, or stinging

Some side effects of penciclovir topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Headache
Less common
  • Change in sense of taste
  • decreased sensitivity of skin, particularly to touch
  • redness of the skin
  • skin rash

For Healthcare Professionals

Applies to penciclovir topical: topical cream


In clinical trials, 1 or more local side effects were reported by 3% of patients using penciclovir topical (the active ingredient contained in Denavir) and 4% of patients using placebo.


Common (1% to 10%): Application site reaction (1%)
Uncommon (0.1% to 1%): Hypesthesia/local anesthesia (less than 1%), erythematous rash (less than 1%)
Frequency not reported: Mild erythema
Postmarketing reports: Local edema, pain, paresthesia, pruritus, skin discoloration, urticaria, aggravated condition, decreased therapeutic response


Uncommon (0.1% to 1%): Taste perversion (less than 1%)
Postmarketing reports: Oral/pharyngeal edema, parosmia

Nervous system

Postmarketing reports: Headache

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