Daclizumab Side Effects

Please note - some side effects for Daclizumab may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Daclizumab - for the Consumer

Daclizumab

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Daclizumab:

Back pain; constipation; coughing; diarrhea; difficult or painful urination; dizziness; fever; gas; generalized weakness; headache; impaired wound healing without infection; increase or decrease in blood pressure; leg cramps; muscle pain; nausea; night sweats; pain; reaction at the injection site; stomach fullness; stomach pain; swelling; swelling of the legs and feet; tiredness; tremors; vomiting.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal heartbeat; chest pain; difficulty swallowing; fast heartbeat; fainting; fluid in the lungs; hoarseness; infection; unusual bruising or bleeding; urinary tract bleeding; weakened immune system.

Side Effects by Body System

Gastrointestinal

Gastrointestinal side effects including constipation, nausea, diarrhea, vomiting, abdominal pain, pyrosis, dyspepsia, abdominal distention, and epigastric pain (not food related) have been reported in at least 5% of patients. Flatulence, gastritis, and hemorrhoids have been reported in between 2% and 5% of patients.

Metabolic

The manufacturer has reported that 32% of 88 daclizumab treated patients had high fasting glucose values compared to 16% of 64 placebo treated patients. Most of these high values occurred either on the first day post-transplant when patients received high doses of corticosteroids or in patients with diabetes.

Metabolic side effects including edema and edema of the extremities have been reported in at least 5% of patients. Fluid overload, diabetes mellitus, and dehydration have been reported in between 2% and 5% of patients.

Nervous system

Nervous system side effects including tremor, headache, dizziness, hypertension, hypotension, and aggravated hypertension have been reported in at least 5% of patients. Leg cramps and prickly sensation have been reported in between 2% and 5% of patients.

Genitourinary

Genitourinary side effects including oliguria, dysuria, and renal tubular necrosis have been reported in at least 5% of patients. Renal damage, urinary retention, hydronephrosis, urinary tract bleeding, urinary tract disorder, and renal insufficiency have been reported in between 2% and 5% of patients.

Hypersensitivity

Hypersensitivity side effects including anaphylaxis have been reported both on initial exposure and following reexposure to daclizumab.

It is recommended that medications used in the treatment of severe hypersensitivity reactions be available for immediate use. If a severe hypersensitivity reaction occurs, therapy with daclizumab should be permanently discontinued.

General

General side effects including posttraumatic pain, insomnia, chest pain, fever, pain, and fatigue have been reported in at least 5% of patients. Shivering and generalized weakness have been reported in between 2% and 5% of patients.

Respiratory

Respiratory side effects including dyspnea, pulmonary edema, and coughing have been reported in at least 5% of patients. Atelectasis, congestion, pharyngitis, rhinitis, hypoxia, rales, abnormal breath sounds, and pleural effusion have been reported in between 2% and 5% of patients.

Dermatologic

Dermatologic side effects including impaired wound healing without infection and acne have been reported in at least 5% of patients. Pruritus, hirsutism, rash, night sweats, and increased sweating have been reported in between 2% and 5% of patients.

Musculoskeletal

Musculoskeletal side effects including musculoskeletal pain and back pain have been reported in at least 5% of patients. Arthralgia and myalgia have been reported in between 2% and 5% of patients.

Cardiovascular

Cardiovascular side effects including tachycardia have been reported in at least 5% of patients.

Hematologic

Hematologic side effects including thrombosis have been reported in at least 5% of patients.

Other

Other side effects including lymphocele have been reported in at least 5% of patients.

Psychiatric

Psychiatric side effects including depression and anxiety have been reported in between 2% and 5% of patients.

Ocular

Ocular side effects including blurred vision have been reported in between 2% and 5% of patients.

Local

Local side effects including application site reaction have been reported in between 2% and 5% of patients.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.