Collagenase Santyl Side Effects

Generic name: collagenase topical

Medically reviewed by Drugs.com. Last updated on Dec 12, 2023.

Note: This document contains side effect information about collagenase topical. Some dosage forms listed on this page may not apply to the brand name Collagenase Santyl.

Applies to collagenase topical: topical application ointment.

Serious side effects of Collagenase Santyl

Along with its needed effects, collagenase topical (the active ingredient contained in Collagenase Santyl) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking collagenase topical:

Incidence not known

Chest tightness
difficulty with swallowing
dizziness
fast heartbeat
fever
hives, itching, skin rash
hoarseness
irritation
joint pain, stiffness, or swelling
redness of the skin
swelling of the eyelids, face, lips, hands, or feet
trouble breathing

Other side effects of Collagenase Santyl

Some side effects of collagenase topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Redness around the wound area

For Healthcare Professionals

Applies to collagenase topical: compounding powder, topical ointment.

General

The most commonly reported side effect was erythema.^[Ref]

Hypersensitivity

Frequency not reported: Systemic manifestations of hypersensitivity (in a patient treated for more than one year with a combination of collagenase and cortisone)^[Ref]