Codeine / Pseudoephedrine / Pyrilamine Side Effects

Applies to codeine/pseudoephedrine/pyrilamine: oral liquid.

Important warnings This medicine can cause some serious health issues

You should not use this medicine if you have inflammatory bowel disease, a blockage in your stomach or intestines, if you have recently been sick with diarrhea, if you are unable to urinate, or if you have used an MAO inhibitor in the past 14 days.

Codeine can slow or stop your breathing. Never use this medicine in larger amounts, or for longer than prescribed. Codeine may also be habit-forming. Never share this medicine with another person. MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH.

Medicines that contain codeine should not be given to a child just after surgery to remove the tonsils or adenoids. Get emergency medical help if a child taking this medicine has breathing problems, blue lips, or severe drowsiness, or if you cannot wake the child up from sleep.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Get emergency medical help if a child taking this medicine has breathing problems, blue lips, or severe drowsiness, or if you cannot wake the child up from sleep.

Stop taking this medicine and call your doctor at once if you have:

• slow heart rate, weak pulse, shallow breathing;

• confusion, mood changes, hallucinations;

• nervousness, severe headache, ringing in your ears;

• severe constipation;

• little or no urination;

• a seizure; or

• easy bruising or bleeding.

Common side effects may include:

• dizziness, drowsiness, tired feeling;

• dry mouth, nose, or throat;

• blurred vision;

• nausea, vomiting, constipation; or

• sleep problems (insomnia).

Side effects such as dry mouth, constipation, and confusion may be more likely in older adults.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to codeine/pseudoephedrine/pyrilamine: oral liquid.

General

The most commonly occurring side effects include dry mouth, dizziness, sleepiness, and disturbed coordination.^[Ref]

Cardiovascular

• Frequency not reported: Hypotension, headache, palpitations, tachycardia, extrasystoles

Respiratory

• Frequency not reported: Nasal dryness, thickening of bronchial secretions, tightness of chest and wheezing, nasal stuffiness, respiratory depression

Psychiatric

• Frequency not reported: Confusion, restlessness, excitation, anxiety, nervousness, irritability, insomnia, euphoria, hysteria, hallucination

Gastrointestinal

• Frequency not reported: Dry mouth, dry throat, epigastric distress, anorexia, nausea, vomiting, diarrhea, constipation

Nervous system

• Frequency not reported: Sedation, sleepiness, dizziness, disturbed coordination, tremor, paresthesias, neuritis, convulsions, CNS depression

Genitourinary

• Frequency not reported: Urinary frequency, difficult urination, urinary retention

Ocular

• Frequency not reported: Blurred vision, diplopia

Other

• Frequency not reported: Chills, fatigue, vertigo, tinnitus

Dermatologic

• Frequency not reported: Drug rash, photosensitivity, excessive perspiration, urticaria

Further information

Codeine/pseudoephedrine/pyrilamine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer