Chlordiazepoxide / clidinium Side Effects

Some side effects of chlordiazepoxide / clidinium may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to chlordiazepoxide / clidinium: oral capsule

Get emergency medical help if you have any of these signs of an allergic reaction while taking chlordiazepoxide / clidinium: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• confusion;

• depressed mood, thoughts of suicide or hurting yourself;

• restless muscle movements in your eyes, tongue, jaw, or neck;

• hyperactivity, agitation, hostility;

• hallucinations;

• jaundice (yellowing of the skin or eyes); or

• urinating less than usual or not at all.

Less serious side effects of chlordiazepoxide / clidinium may include:

• drowsiness, tiredness;

• swelling;

• skin rash;

• blurred vision;

• dry mouth;

• nausea, vomiting, constipation; or

• irregular menstrual periods.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to chlordiazepoxide / clidinium: oral capsule

Nervous system

The elderly and debilitated may be more susceptible to the side effects of chlordiazepoxide-clidinium. Drowsiness, ataxia, and confusion have occasionally been reported at the lower dosage ranges.

Nervous system side effects have included drowsiness, ataxia, confusion, and extrapyramidal symptoms. Chlordiazepoxide-clidinium may impair the psychomotor skills necessary for driving. Changes in electroencephalogram (EEG) patterns (low-voltage fast activity) have been reported during and after chlordiazepoxide treatment.

Gastrointestinal

Gastrointestinal side effects have included nausea, constipation, and dryness of the mouth.

Hematologic

Hematologic side effects have included blood dyscrasias (including agranulocytosis).

Hepatic

Hepatic side effects have included jaundice and hepatic dysfunction.

Other

Withdrawal symptoms after abrupt cessation of chlordiazepoxide-clidinium may include dysphoria, insomnia, convulsions, tremor, abdominal and muscle cramps, vomiting, sweating, agitation, restlessness, and anxiety.

Other side effects have included increased and decreased libido, edema, and withdrawal symptoms. Rarely, syncope has been reported.

Ocular

Ocular side effects have included blurring of vision.

Genitourinary

Genitourinary side effects have included minor menstrual irregularities and urinary hesitancy.

Dermatologic

Dermatologic side effects have included skin eruptions.

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