Chlordiazepoxide / Clidinium Dosage

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Usual Adult Dose for:

Usual Geriatric Dose for:

Additional dosage information:

Usual Adult Dose for Peptic Ulcer

Chlordiazepoxide 5 mg-clidinium 2.5 mg oral capsule: 1 or 2 capsules orally 3 or 4 times daily before meals and at bedtime

Usual Adult Dose for Irritable Bowel Syndrome

Chlordiazepoxide 5 mg-clidinium 2.5 mg oral capsule: 1 or 2 capsules orally 3 or 4 times daily before meals and at bedtime

Usual Adult Dose for Enterocolitis

Chlordiazepoxide 5 mg-clidinium 2.5 mg oral capsule: 1 or 2 capsules orally 3 or 4 times daily before meals and at bedtime

Usual Geriatric Dose for Peptic Ulcer

Chlordiazepoxide 5 mg-clidinium 2.5 mg oral capsule: 1 capsule orally twice daily
Dose may be increased gradually as needed and tolerated.

Usual Geriatric Dose for Irritable Bowel Syndrome

Chlordiazepoxide 5 mg-clidinium 2.5 mg oral capsule: 1 capsule orally twice daily
Dose may be increased gradually as needed and tolerated.

Usual Geriatric Dose for Enterocolitis

Chlordiazepoxide 5 mg-clidinium 2.5 mg oral capsule: 1 capsule orally twice daily
Dose may be increased gradually as needed and tolerated.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Chlordiazepoxide-clidinium is contraindicated in patients with glaucoma, prostatic hypertrophy, and benign bladder neck obstruction.

Suicide is an inherent risk in depressed patients with anxiety. Patients should be closely supervised and dispensed the smallest quantity of drug possible while receiving chlordiazepoxide.

Occasionally, blood dyscrasias (including agranulocytosis), jaundice, and hepatic dysfunction have occurred during treatment with chlordiazepoxide. During extended treatment, periodic blood counts and liver function tests are recommended.

Chlordiazepoxide is habit forming. Addiction prone individuals (such as alcoholics, and drug addicts) should be monitored closely if they receive chlordiazepoxide or other psychotropic agents because of the predisposition of such patients to habituation and dependence.

Withdrawal symptoms (convulsions, tremor, abdominal and muscle cramps, vomiting and sweating) have occurred following abrupt discontinuation of chlordiazepoxide. The more severe withdrawal symptoms have been limited to those patients who had received excessive doses over an extended period of time. It is recommended that patients on prolonged therapies avoid abrupt discontinuation, and follow a gradual dosage tapering.

Patients with renal and/or hepatic dysfunction should be treated with chlordiazepoxide-clidinium cautiously.

Safety and efficacy of chlordiazepoxide-clidinium have not been established in pediatric patients.

Dialysis

Data not available

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