Capreomycin Side Effects
Not all side effects for capreomycin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to capreomycin: injection powder for solution
In addition to its needed effects, some unwanted effects may be caused by capreomycin. In the event that any of these side effects do occur, they may require medical attention.
If any of the following side effects occur while taking capreomycin, check with your doctor or nurse as soon as possible:More common
- Greatly increased or decreased frequency of urination or amount of urine
- increased thirst
- loss of appetite
- Any loss of hearing
- clumsiness or unsteadiness
- difficulty in breathing
- irregular heartbeat
- muscle cramps or pain
- pain, redness, hardness, unusual bleeding, or a sore at the place of injection
- ringing or buzzing or a feeling of fullness in the ears
- skin rash
- unusual tiredness or weakness
For Healthcare Professionals
Applies to capreomycin: intramuscular powder for injection
Renal side effects have included dose-related nephrotoxicity, including BUN elevations (greater than 20 mg/dL) (36%), BUN elevations (greater than 30 mg/dL) (10%), depression of PSP excretion, abnormal urine sediment, renal insufficiency, and oliguria. At least one case of toxic nephritis and acute tubular necrosis has been reported.[Ref]
A patient with tuberculosis and portal cirrhosis experienced toxic nephritis and acute tubular necrosis coincident with capreomycin therapy. The patient was treated with capreomycin therapy (1 g) and aminosalicylic acid daily for 1 month. The patient developed renal insufficiency and oliguria and died. The autopsy showed subsiding acute tubular necrosis.[Ref]
Nervous system side effects have included ototoxicity and vestibular toxicity including subclinical auditory loss (11%), clinically apparent hearing loss (3%), vertigo, and tinnitus.[Ref]
Local side effects have included pain, induration, and excessive bleeding at the injection site.[Ref]
Hematologic side effects have included leukocytosis, leukopenia, and eosinophilia. Thrombocytopenia has also been reported rarely.[Ref]
Hepatic side effects have included decreased BSP excretion.[Ref]
Metabolic side effects including hypokalemia, hypocalcemia, hypomagnesemia, and electrolyte disturbances resembling Bartter's syndrome have been reported.[Ref]
1. "Product Information. Capastat Sulfate (capreomycin)." Dura Pharmaceuticals, San Diego, CA.
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