Calci Mix Side Effects

Generic Name: calcium carbonate

Please note - some side effects for Calci Mix may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects by Body System

Gastrointestinal

Rebound hyperacidity has been associated with calcium salt antacids. This side effect does not appear to be due to the acid buffering capacity of calcium carbonate, but is a consequence of a specific action of calcium on the parietal cell.

Rare cases of calcium carbonate gallstones have been reported in the pediatric literature.

Gastrointestinal side effects have included rebound hyperacidity, constipation (6% to 37%) and gallstones (rarely).

Metabolic

Prolonged ingestion of large amounts of calcium carbonate and other sources of exogenous calcium can rarely result in the "milk alkali syndrome" and calcinosis. The milk alkali syndrome is characterized by the triad of hypercalcemia, metabolic alkalosis, and renal insufficiency.

Metabolic side effects have rarely included hypercalcemia and hypophosphatemia. Hypercalcemia may be more likely and more severe in patients with renal dysfunction. In patients on chronic dialysis, hypercalcemia may also result from excessive calcium in the dialysate, vitamin D intoxication, or severe secondary hyperparathyroidism. Other metabolic side effects have rarely included "mild alkali syndrome", calcinosis, and irreversible renal damage.

Renal

Renal side effects have included renal failure, formation of renal calcium and a single case report of a calcium carbonate and calcium phosphate-filled renal cyst.

The renal failure that accompanies hypercalcemia and alkalosis in the milk alkali syndrome is usually transient.

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