Bosulif Side Effects

Generic Name: bosutinib

Note: This page contains information about the side effects of bosutinib. Some of the dosage forms included on this document may not apply to the brand name Bosulif.

Not all side effects for Bosulif may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to bosutinib: oral tablet

Along with its needed effects, bosutinib (the active ingredient contained in Bosulif) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking bosutinib:

More common
  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • chills
  • cough
  • difficult or labored breathing
  • fever
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • shortness of breath
  • sore throat
  • swelling of the hands, ankles, feet, or lower legs
  • tightness in the chest
  • troubled breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • wheezing
Less common
  • Abdominal or stomach pain or tenderness
  • agitation
  • chest pain or discomfort
  • clay-colored stools
  • cough with mucus
  • confusion
  • dark urine
  • decreased appetite
  • decreased urination
  • depression
  • diarrhea
  • dizziness
  • dry mouth
  • fainting
  • fast or irregular heartbeat
  • general feeling of discomfort or illness
  • headache
  • hives
  • hoarseness
  • hostility
  • increased sweating
  • increased thirst
  • irritation
  • itching
  • joint pain, stiffness or swelling
  • lightheadedness
  • loss of appetite
  • muscle aches, pains, or twitching
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • rapid breathing
  • rapid weight gain
  • redness of the skin
  • runny nose
  • seizures
  • shivering
  • skin rash
  • sneezing
  • sunken eyes
  • swelling of the eyelids, face, lips, hands, or feet
  • thirst
  • trouble sleeping
  • trouble swallowing
  • weakness or heaviness of the legs
  • wrinkled skin
Rare
  • Anxiety
  • blistering, peeling, loosening of the skin
  • bloating
  • blue lips, fingernails, or skin
  • chest pain, possibly moving to the left arm, neck, or shoulder
  • constipation
  • coughing that sometimes produces a pink frothy sputum
  • difficult, noisy breathing, sometimes with wheezing
  • indigestion
  • irregular, fast or slow, or shallow breathing
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • red, irritated eyes
  • vomiting of blood or material that looks like coffee grounds
  • yellow eyes or skin

Some side effects of bosutinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Back pain
  • difficulty with moving
  • lack or loss of strength
  • muscle stiffness
  • stuffy nose
Less common
  • Blemishes on the skin
  • burning feeling in the chest or stomach
  • change in taste
  • hearing loss
  • loss of taste
  • muscle cramping
  • pimples
  • ringing, buzzing, or other unexplained noise in the ears that continues
  • stomach upset
  • tenderness in the stomach area
Rare
  • Flaking and falling off of the skin

For Healthcare Professionals

Applies to bosutinib: oral tablet

General

Serious adverse reactions reported include anaphylactic shock, myelosuppression, gastrointestinal toxicity (diarrhea), fluid retention, hepatotoxicity and rash.

Gastrointestinal

Very common (10% or more): Diarrhea (82%), nausea (46%), vomiting (39%), abdominal pain (37%)
Common (1% to 10%): Gastritis
Uncommon (0.1% to 1%): Acute pancreatitis, gastrointestinal hemorrhage

Hematologic

Very common (10% or more): Thrombocytopenia (41%), anemia (27%), neutropenia (17%)
Common (1% to 10%): Febrile neutropenia

Hepatic

Very common (10% or more): Alanine aminotransferase increased (17%), aspartate aminotransferase increased (14%)
Common (1% to 10%): Hepatotoxicity, abnormal hepatic function
Uncommon (0.1% to 1%): Liver injury

Dermatologic

Very common (10% or more): Rash (35%), pruritus (10%)
Common (1% to 10%): Urticaria, pruritus, acne
Uncommon (0.1% to 1%): Erythema multiforme, exfoliative rash, drug eruption

Cardiovascular

Common (1% to 10%): Pericardial effusion
Uncommon (0.1% to 1%): Pericarditis

Hypersensitivity

Common (1% to 10%): Drug hypersensitivity
Uncommon (0.1% to 1%): Anaphylactic shock

Respiratory

Very common (10% or more): Cough (20%), dyspnea (12%), respiratory tract infection (12%), nasopharyngitis (10%),
Common (1% to 10%): Pneumonia, influenza, bronchitis, pleural effusion
Uncommon (0.1% to 1%): Acute pulmonary edema, respiratory failure, pulmonary hypertension

Metabolic

Very common (10% or more): Decreased appetite (13%)
Common (1% to 10%): Increased blood creatine phosphokinase, increased blood creatinine, hyperkalemia, dehydration

Musculoskeletal

Very common (10% or more): Arthralgia (14%), back pain (11%)
Common (1% to 10%): Myalgia

Nervous system

Very common (10% or more): Headache (20%), dizziness (10%)
Common (1% to 10%): Tinnitus, dysgeusia

Other

Very common (10% or more): Pyrexia (26%), fatigue (24%), edema (14%), asthenia (11%)
Common (1% to 10%): Chest pain, pain, prolonged QT interval

Renal

Common (1% to 10%): Acute renal failure, renal failure

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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