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Azilect Side Effects

Generic Name: rasagiline

Note: This document contains side effect information about rasagiline. Some of the dosage forms listed on this page may not apply to the brand name Azilect.

Some side effects of Azilect may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to rasagiline: oral tablet

Along with its needed effects, rasagiline (the active ingredient contained in Azilect) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking rasagiline:

Less common
  • Abdominal or stomach pain
  • arm, back, or jaw pain
  • black, tarry stools
  • chest pain or discomfort
  • chest tightness or heaviness
  • chills
  • cloudy urine
  • cough
  • diarrhea
  • difficulty swallowing
  • dizziness
  • fainting
  • fast or irregular heartbeat
  • fever
  • hives
  • itching
  • loss of appetite
  • nausea
  • painful or difficult urination
  • persistent, non-healing sore
  • pink growth on skin
  • puffiness or swelling of the eyelids or around the eyes
  • reddish patch or irritated area
  • redness, blistering, peeling, or loosening of the skin
  • seeing, hearing, or feeling things that are not there
  • shiny bump
  • shortness of breath
  • skin rash
  • sore throat
  • sores, ulcers, or white spots on lips or in mouth
  • sweating
  • swollen glands
  • tests that show problems with the liver
  • tightness in chest
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • weakness
  • wheezing
  • white, yellow or waxy scar-like area

Some side effects of rasagiline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Acid or sour stomach
  • belching
  • difficulty in moving
  • headache
  • heartburn
  • indigestion
  • muscle pain or stiffness
  • pain in joints
  • stomach discomfort or upset
Less common
  • Bruising
  • burning, crawling, itching, numbness, prickling, "pins and needles" or tingling feelings
  • burning, dry, or itching eyes
  • decreased interest in sexual intercourse
  • difficulty breathing
  • difficulty in moving
  • discouragement
  • excessive tearing
  • eye discharge
  • fall
  • feeling of constant movement of self or surroundings
  • feeling sad or empty
  • general feeling of discomfort or illness
  • hair loss
  • inability to have or keep an erection
  • irritability
  • joint pain
  • lack of appetite
  • large, flat, blue or purplish patches in the skin
  • light-headedness
  • loss in sexual ability, desire, drive, or performance
  • loss of interest or pleasure
  • muscle aches
  • neck pain
  • noisy breathing
  • redness, pain, swelling of eye, eyelid, or inner lining of eyelid
  • runny nose
  • sensation of spinning
  • shivering
  • sneezing
  • stuffy nose
  • swelling or redness in joints
  • thinning of hair
  • tiredness
  • trouble concentrating
  • trouble sleeping
  • vomiting
  • weight loss

For Healthcare Professionals

Applies to rasagiline: oral tablet

General

General side effects have included accidental injury (10.1%), malaise, headache, fall, fever, flu syndrome, paresthesia, vertigo, hernia, sweating, somnolence, and weight loss.

Gastrointestinal

Gastrointestinal side effects have included nausea (7.2%), vomiting (3.7% to 6.7%), dyspepsia, gastroenteritis, diarrhea, anorexia, constipation, dry mouth, abdominal pain, and gingivitis.

Dermatologic

Dermatologic side effects have included ecchymosis, rash, pruritus, skin ulcer, eczema, urticaria, exfoliative dermatitis, leukoderma, and skin carcinoma.

Hematologic

Hematologic side effects have included hemorrhage, macrocytic anemia, purpura, and thrombocythemia.

Immunologic

Immunologic side effects have included infection (14.9%).

Cardiovascular

Cardiovascular side effects have included orthotopic hypertension (6%), postural hypotension, bundle branch block, heart failure, myocardial infarct, ventricular tachycardia, arterial thrombosis, atrial arrhythmia, complete AV block, second degree AV block, bigeminy, ventricular fibrillation, and peripheral edema.

Musculoskeletal

Musculoskeletal side effects have included dyskinesia (1%), arthralgia, myasthenia, tenosynovitis, neck pain, ataxia, dystonia, bone necrosis, muscle atrophy, and arthrosis.

Respiratory

Respiratory side effects have included dyspnea, increased cough, apnea, emphysema, laryngismus, pleural effusion, pneumothorax, interstitial pneumonia, larynx edema, lung fibrosis, and rhinitis.

Psychiatric

Psychiatric side effects have included hallucinations (1% to 3%) and abnormal dreams.

Genitourinary

Genitourinary side effects have included hematuria, urinary incontinence, dysmenorrhea, dysuria, nocturia, polyuria, scrotal edema, urinary retention, vaginal hemorrhage, vaginitis, vaginal moniliasis, abnormal ejaculation, amenorrhea, epididymitis, gynecomastia, hydroureter, leukorrhea, priapism, and urinary tract infection.

Metabolic

Metabolic side effects have included weight loss (2.4% to 9.4%) and hypocalcemia.

Nervous system

Nervous system side effects have included confusion (1%), headache, abnormal gait, anxiety, hyperkinesia, hypertonia, neuropathy, tremor, agitation, aphasia, circumoral paresthesia, convulsion, delusions, dementia, dysarthria, dysautonomia, dysesthesia, emotional lability, facial paralysis, foot drop, hemiplegia, hypesthesia, incoordination, manic reaction, myoclonus, neuritis, neurosis, paranoid reaction, personality disorder, psychosis, and wrist drop. Apathy, delirium, hostility, manic depressive reaction, myelitis, neuralgia, psychotic depression and stupor have been reported rarely. Pain, back pain, dizziness, and balance difficulty have also been reported.

Oncologic

Oncologic side effects including melanoma have been reported.

Ocular

Ocular side effects including xerostomia and conjunctivitis have been reported.

Other

Other side effects have included asthenia (10.9%), accidental injury (10.1%), malaise, fall, flu syndrome, vertigo, and hernia.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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