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Avacopan Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 9, 2023.

Applies to avacopan: oral capsule.

Serious side effects of Avacopan

Along with its needed effects, avacopan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking avacopan:

More common

Less common

Other side effects of Avacopan

Some side effects of avacopan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to avacopan: oral capsule.

General

The most common adverse reactions occurring in 5% of patients or greater included nausea, headache, diarrhea, vomiting, rash, upper abdominal pain, and dizziness.[Ref]

Cardiovascular

Very common (10% or more): Hypertension (18%)[Ref]

Dermatologic

Very common (10% or more): Rash (11%)

Common (1% to 10%): Alopecia, pruritus, cellulitis, angioedema[Ref]

Endocrine

Common (1% to 10%): Cushingoid[Ref]

Gastrointestinal

Very common (10% or more): Nausea (24%), diarrhea (15%), vomiting (15%)

Common (1% to 10%): Upper abdominal pain, constipation, dyspepsia, oral candidiasis, oral herpes, gastroenteritis[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection[Ref]

Hematologic

Very common (10% or more): Decreased white blood cell count (19%)

Common (1% to 10%): Anemia, leukopenia, lymphopenia, neutropenia, increased tendency to bruise

Uncommon (0.1% to 1%): Agranulocytosis[Ref]

Hepatic

Very common (10% or more): Increased liver function test (up to 13.3%)

Frequency not reported: Hepatitis B reactivation[Ref]

Increased liver function test (LFT) included elevated ALT and bilirubin, abnormal hepatic function, increased gamma-glutamyl transferase, increased hepatic enzyme, and increased transaminase. In another study increased LFT included hepatitis, hepatitis cholestasis, hepatocellular injury, asymptomatic hepatitis, cytolysis, and anicteric cholestasis without hepatocellular insufficiency.[Ref]

Immunologic

Very common (10% or more): ANCA-positive vasculitis (16%)[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia (19%), muscle spasms (11%)

Common (1% to 10%): Back pain, myalgia, pain in extremity[Ref]

Nervous system

Very common (10% or more): Headache (21%)

Common (1% to 10%): Dizziness, paresthesia, tremor[Ref]

Other

Very common (10% or more): Peripheral edema (21%), fatigue (10%)

Common (1% to 10%): Herpes zoster, bruising, increased creatine phosphokinase, pyrexia, otitis media

Uncommon (0.1% to 1%): Weight increased[Ref]

Renal

Common (1% to 10%): Increased serum creatinine, acute kidney injury[Ref]

Respiratory

Very common (10% or more): Cough (16%), nasopharyngitis (15%), upper respiratory tract infection (15%)

Common (1% to 10%): Pneumonia, sinusitis, oropharyngeal pain, bronchitis, epistaxis, dyspnea, lower respiratory tract infection, influenza, rhinitis[Ref]

Psychiatric

Common (1% to 10%): Insomnia[Ref]

References

1. Product Information. Tavneos (avacopan). ChemoCentryx, Inc. 2021.

2. Product Information. Tavneos (avacopan). Vifor Pharma Pty Ltd. 2023.

3. Product Information. Tavneos (avacopan). Vifor Fresenius Medical Care Renal Pharma UK Ltd. 2023.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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