Avacopan Dosage

Medically reviewed by Drugs.com. Last updated on Aug 2, 2022.

Usual Adult Dose for Vasculitis

30 mg orally twice a day with food

Use: As an adjunctive treatment of patients with severe active anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (granulomatosis with polyangiitis and microscopic polyangiitis) in combination with standard therapy including glucocorticoids; this drug does not eliminate glucocorticoid use.

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Mild or Moderate Liver Dysfunction (Child-Pugh A or B): No adjustment recommended
Severe Liver Dysfunction (Child-Pugh C) or Cirrhosis: Use is not recommended

Dose Adjustments

Concomitant Use of Strong CYP450 3A4 Inhibitors:

• Reduce dose to 30 mg once a day

Precautions

CONTRAINDICATIONS: Serious hypersensitivity reaction to this drug or to any of the excipients

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• Administer this drug with a meal.
• Swallow capsules whole; do not crush, chew, or open capsules.
• If a dose is missed, patient should wait until the usual scheduled time to take the next regular dose. Instruct patient not to double the next dose.

Storage requirements:

• Do not use if seal is broken or missing.
• Store at 20C to 25C (68F to 77F)

Monitoring:

• Hepatic:
• Liver function tests: ALT, AST, alkaline phosphate, and total bilirubin (prior to and during treatment as clinically appropriate)
• Hepatitis B Serology (prior to and during treatment as clinically appropriate; consult a physician with expertise in managing hepatitis B regarding monitoring)

Patient advice:

• Read the FDA-approved patient labeling (Medication Guide).
• Seek immediate medical attention if experiencing signs and symptoms suggesting angioedema; discontinue treatment and consult your health care provider.
• Contact your health care provider if experiencing signs and symptoms of liver problems.
• Report all signs or symptoms of infection to your health care provider immediately.
• Discuss the benefits/risks of breastfeeding during treatment with this drug with your health care provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer