Aricept Side Effects

Generic Name: donepezil

Note: This document contains side effect information about donepezil. Some of the dosage forms listed on this page may not apply to the brand name Aricept.

Some side effects of Aricept may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to donepezil: oral tablet, oral tablet disintegrating

Along with its needed effects, donepezil (the active ingredient contained in Aricept) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking donepezil:

More common
  • Diarrhea
  • loss of appetite
  • muscle cramps
  • nausea
  • trouble in sleeping
  • unusual tiredness or weakness
  • vomiting
Less common
  • Abnormal dreams
  • constipation
  • dizziness
  • drowsiness
  • fainting
  • frequent urination
  • headache
  • joint pain, stiffness, or swelling
  • mental depression
  • pain
  • unusual bleeding or bruising
  • weight loss
Rare
  • Black, tarry stools
  • bloating
  • bloody or cloudy urine
  • blurred vision
  • burning, prickling, or tingling sensations
  • cataract
  • chills
  • clumsiness or unsteadiness
  • confusion
  • cough
  • decreased urination
  • difficult or painful urination
  • dryness of mouth
  • eye irritation
  • fever
  • flushing of skin
  • frequent urge to urinate
  • high or low blood pressure
  • hives
  • hot flashes
  • increase in sexual desire or performance
  • increased heart rate and breathing
  • increased sweating
  • increased urge to urinate during the night
  • irregular heartbeat
  • itching
  • loss of bladder control
  • loss of bowel control
  • mood or mental changes, including abnormal crying, aggression, agitation, delusions, irritability, nervousness, or restlessness
  • nasal congestion
  • pain in chest, upper stomach, or throat
  • problems with speech
  • runny nose
  • severe thirst
  • shortness of breath
  • sneezing
  • sore throat
  • sunken eyes
  • tightness in chest
  • tremor
  • troubled breathing
  • wheezing
  • wrinkled skin
Incidence not known
  • Back, leg, or stomach pains
  • bleeding gums
  • chest pain or discomfort
  • coma
  • convulsions
  • dark urine
  • difficulty breathing
  • fast or irregular heartbeat
  • fatigue
  • general body swelling
  • general tiredness and weakness
  • high fever
  • increased thirst
  • indigestion
  • light-colored stools
  • muscle pain or cramps
  • nausea and vomiting
  • nosebleeds
  • pains in stomach, side, or abdomen, possibly radiating to the back
  • pale skin
  • rash
  • seeing, hearing, or feeling things that are not there
  • seizures
  • severe muscle stiffness
  • severe nausea
  • slow or irregular heartbeat
  • stomach pain
  • sweating
  • swelling of face, ankles, or hands
  • tiredness
  • unusually pale skin
  • upper right abdominal or stomach pain
  • yellow eyes and skin
Symptoms of overdose
  • Convulsions (seizures)
  • increased sweating
  • increased watering of mouth
  • increasing muscle weakness
  • low blood pressure
  • severe nausea
  • severe vomiting
  • slow heartbeat
  • troubled breathing

For Healthcare Professionals

Applies to donepezil: oral tablet, oral tablet disintegrating

Nervous system

The case of restless legs, mumbling, and stuttering resolved after discontinuation of donepezil (the active ingredient contained in Aricept) and there was a positive rechallenge.

Nervous system side effects have included headache (10%), insomnia (up to 9%), dizziness (up to 8%), hostility (3%), nervousness (3%), hallucinations (3%), somnolence (2%), depression (2%), confusion (2%), emotional lability (2%), and personality disorder (2%). Delusions, tremor, irritability, paresthesia, aggression, vertigo, ataxia, increased libido, restlessness, abnormal crying, and aphasia have been reported frequently. Cerebrovascular accident, intracranial hemorrhage, transient ischemic attack, neuralgia, coldness (localized), muscle spasm, dysphoria, gait abnormality, hypertonia, hypokinesia, neurodermatitis, numbness (localized), paranoia, dysarthria, dysphasia, decreased libido, melancholia, emotional withdrawal, nystagmus, and pacing have been reported infrequently. A case of Pisa Syndrome and a dose-related case of restless legs, mumbling, and stuttering have been reported. Two cases of worsening Parkinson's disease, a case report of convulsions, and a case report of delirium which may possibly have been associated with the use of donepezil have also been reported.

Genitourinary

Genitourinary side effects including incontinence (7%) have been reported. Nocturia has been reported frequently. Dysuria, hematuria, urinary urgency, metrorrhagia, cystitis, enuresis, prostate hypertrophy, pyelonephritis, inability to empty bladder, breast fibroadenosis, fibrocystic breast, mastitis, pyuria, renal failure, and vaginitis have been reported infrequently.

Musculoskeletal

Musculoskeletal side effects including muscle cramps (6%) and back pain (3%) have been reported. Bone fracture has been reported frequently. Muscle weakness, and muscle fasciculation have been reported infrequently.

Gastrointestinal

Gastrointestinal side effects reported in at least 5% of patients include nausea, vomiting, diarrhea, and anorexia. Fecal incontinence, gastrointestinal bleeding, bloating, and epigastric pain have been reported frequently. Eructation, gingivitis, increased appetite, flatulence, periodontal abscess, cholelithiasis, diverticulitis, drooling, dry mouth, fever sore, gastritis, irritable colon, tongue edema, epigastric distress, gastroenteritis, increased transaminases, hemorrhoids, ileus, increased thirst, jaundice, melena, polydipsia, duodenal ulcer, and stomach ulcer have been reported infrequently.

Dermatologic

Dermatologic side effects including eczema (3%) have been reported. Pruritus, diaphoresis, and urticaria have been reported frequently. Dermatitis, erythema, skin discoloration, hyperkeratosis, alopecia, fungal dermatitis, herpes zoster, hirsutism, skin striae, night sweats, and skin ulcer have been reported infrequently. A case of purpuric rash has been reported.

Cardiovascular

Cardiovascular side effects including hypertension (up to 3%), hemorrhage (up to 2%), and syncope (2%) have been reported. Hypotension and bradycardia have been reported in less than 1% of patients. Vasodilation, atrial fibrillation, hot flashes, and hypotension have been reported frequently. Angina pectoris, postural hypotension, myocardial infarction, AV block (first degree), congestive heart failure, arteritis, bradycardia, peripheral vascular disease, supraventricular tachycardia, and deep vein thrombosis have been reported infrequently.

Metabolic

Metabolic side effects have included dehydration (2%), hyperlipemia (2%), and weight loss with increasing dosage. Gout, hypokalemia, increased creatine kinase, hyperglycemia, increased weight, and increased lactate dehydrogenase have been reported infrequently.

General

Frequency of common adverse effects may be influenced by the rate of titration.

General side effects including fever (2%) and chest pain (2%) have been reported. Fever, facial edema, periorbital edema, hiatal hernia, abscess, cellulitis, chills, generalized coldness, head fullness, and listlessness have been reported infrequently. Side effects are generally mild in nature and well tolerated.

Other

Other side effects including earache, tinnitus, decreased hearing, otitis externa, otitis media, bad taste, ear buzzing, and motion sickness have been reported infrequently. Cholinergic effects such as frequent urination have been reported in 2% of patients. Tremor, restlessness, hypertension, hypotension, ataxia, bradycardia, and diaphoresis have been reported in less than 1% of patients.

Ocular

Ocular side effects including cataract, eye irritation, and blurred vision have been reported frequently. Dry eyes, glaucoma, blepharitis, retinal hemorrhage, conjunctival hemorrhage, and spots before eyes have been reported infrequently.

Endocrine

Endocrine side effects including diabetes mellitus and goiter have been reported infrequently.

Hematologic

Hematologic side effects including anemia, thrombocythemia, thrombocytopenia, eosinophilia, and erythrocytopenia have been reported infrequently.

Respiratory

Respiratory side effects including dyspnea, sore throat, and bronchitis have been reported frequently. Epistaxis, post nasal drip, pneumonia, hyperventilation, pulmonary congestion, wheezing, hypoxia, pharyngitis, pleurisy, pulmonary collapse, sleep apnea, and snoring have been reported infrequently.

Psychiatric

Psychiatric side effects including nightmares have been reported.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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