AK-Dex Side Effects

Generic Name: dexamethasone ophthalmic

Note: This document contains side effect information about dexamethasone ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name AK-Dex.

Some side effects of AK-Dex may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to dexamethasone ophthalmic: intraocular implant

Along with its needed effects, dexamethasone ophthalmic (the active ingredient contained in AK-Dex) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking dexamethasone ophthalmic:

More common
  • Bloody eye
  • blurred vision
  • change in vision
  • eye pain
  • loss of vision
  • redness of the white part of the eye or inside of the eyelid
Less common
  • Blindness
  • decreased vision
  • gradual loss of vision
  • headache
  • nausea
  • seeing a veil or curtain across part of your vision
  • seeing flashes or sparks of light
  • seeing floating spots before the eyes
  • vomiting

For Healthcare Professionals

Applies to dexamethasone ophthalmic: intraocular implant, ophthalmic ointment, ophthalmic solution, ophthalmic suspension


Ocular side effects have included elevation of intraocular pressure with possible development of glaucoma, visual acuity and visual field defects, subcapsular cataract formation, optic nerve damage, secondary ocular infection and perforation of the globe. Less frequent side effects of dexamethasone ophthalmic (the active ingredient contained in AK-Dex) include burning and stinging upon instillation.

Corticosteroid containing preparations have also been reported to cause acute anterior uveitis, keratitis, conjunctivitis, corneal ulcers, mydriasis, conjunctival hyperemia, loss of accommodation, and ptosis.

Adverse effects associated with the dexamethasone intravitreal implant include increased intraocular pressure, conjunctival hemorrhage, eye pain, conjunctival hyperemia, ocular hypertension, cataract, and vitreous detachment.

Postmarketing reports concerning dexamethasone intravitreal implant include complication of device insertion (implant misplacement), device dislocation with or without corneal edema, endophthalmitis, and hypotony of the eye (associated with vitreous leakage due to injection).

Nervous system

Nervous system side effects associated with dexamethasone intravitreal implant include headache.

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