Adcetris Side Effects
Generic Name: brentuximab
Note: This document contains side effect information about brentuximab. Some of the dosage forms listed on this page may not apply to the brand name Adcetris.
Some side effects of Adcetris may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to brentuximab: intravenous powder for solution
Along with its needed effects, brentuximab (the active ingredient contained in Adcetris) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking brentuximab:More common
- Black, tarry stools
- bleeding gums
- blood in the urine or stools
- body aches or pain
- burning, numbness, tingling, or painful sensations
- difficult or labored breathing
- difficulty with breathing
- ear congestion
- loss of voice
- lower back or side pain
- painful or difficult urination
- pale skin
- pinpoint red spots on the skin
- shortness of breath
- sore throat
- stuffy or runny nose
- swollen, painful, or tender lymph glands in the neck, armpit, or groin
- tightness in the chest
- troubled breathing with exertion
- ulcers, sores, or white spots in the mouth
- unsteadiness or awkwardness
- unusual bleeding or bruising
- unusual tiredness or weakness
- weakness in the arms, hands, legs, or feet
- back pain
- bladder pain
- blistering, peeling, or loosening of the skin
- bloating or swelling of the face, arms, hands, lower legs, or feet
- blurred vision
- chest pain
- cloudy urine
- dizziness or lightheadedness
- fast heartbeat
- frequent urge to urinate
- general feeling of discomfort or illness
- irregular heartbeat
- joint pain, stiffness, or swelling
- muscle pain
- rapid weight gain
- red skin lesions, often with a purple center
- red, irritated eyes
- severe pain in the chest
- stomach pain
- sudden onset of severe breathing difficulty
- sudden shortness of breath or troubled breathing
- thickening of bronchial secretions
- troubled breathing
- unusual weight gain or loss
Some side effects of brentuximab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Decreased appetite or weight
- difficulty having a bowel movement (stool)
- difficulty with moving
- hair loss or thinning of the hair
- muscle spasms
- muscle stiffness
- night sweats
- pain in the arms or legs
- trouble with sleeping
- unable to sleep
- Dry skin
For Healthcare Professionals
Applies to brentuximab: intravenous powder for injection
Dermatologic side effects have included rash (less than 31%), pruritus (less than 19%, alopecia (less than 14%), night sweats (less than 12%), and dry skin (less than 10%).
Gastrointestinal side effects have included nausea (less than 42%), diarrhea (less than 36%), abdominal pain (less than 25%), vomiting (less than 22%) and constipation (less than 19%).
General side effects have included fatigue (less than 49%), pyrexia (less than 38%), pain (less than 28%), peripheral edema (less than 16%), and chills (less than 13%).
Hematologic side effects have included neutropenia (less than 55%), anemia (less than 52%), thrombocytopenia (less than 28%), and lymphadenopathy (less than 11%).
Hypersensitivity reactions have included anaphylaxis (less than 2%).
Metabolic side effects have included decreased appetite (less than 16%) and decreased weight (less than 12%).
Musculoskeletal side effects have included arthralgia (less than 19%), myalgia (less than 17%), back pain (less than 14%), pain in extremity (less than 10%), and muscle spasms (less than 10%).
Nervous system side effects have included peripheral sensory neuropathy (less than 53%), headache (less than 19%), peripheral motor neuropathy (less than 16%), and dizziness (less than 16%).
Other side effects have included infusion related reactions (12%) including chills, nausea, dyspnea, pruritus, pyrexia and cough.
Psychiatric side effects have included insomnia (less than 16%) and anxiety (less than 11%).
Respiratory side effects have included upper respiratory tract infection (less than 47%), cough (less than 25%), dyspnea (less than 19%), and oropharyngeal pain (less than 11%).
More about Adcetris (brentuximab)
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