Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine Side Effects

Please note - some side effects for Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine - for the Consumer

Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine: Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine:

Dizziness; excitability; headache; nausea; nervousness or anxiety; trouble sleeping; weakness.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; difficulty urinating; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; stomach pain; tremor; yellowing of skin or eyes.

Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine Liquid

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine Liquid: Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Acetaminophen/Dextromethorphan/Guaifenesin/Phenylephrine Liquid:

Dizziness; drowsiness; excitability; headache; nausea; nervousness or anxiety; trouble sleeping.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; difficulty urinating; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; stomach pain; tremor; yellowing of skin or eyes.

Side Effects by Body System

Cardiovascular

Cardiovascular side effects of phenylephrine have included palpitations, arrhythmias, and cardiovascular collapse with hypotension.

Gastrointestinal

Gastrointestinal side effects of dextromethorphan have included upset stomach.

Gastrointestinal side effects of guaifenesin have included stomach upset and vomiting with higher than recommended doses. Doses recommended for expectoration have rarely been associated with gastrointestinal upset.

Gastrointestinal side effects of phenylephrine have included nausea.

General

General side effects of phenylephrine have included pallor and weakness.

Genitourinary

Genitourinary side effects of phenylephrine have included dysuria.

Hepatic

Hepatic side effects of acetaminophen have included severe and sometimes fatal dose dependent hepatitis in alcoholic patients. Hepatotoxicity has been increased during fasting.

Hypersensitivity

Hypersensitivity side effects of dextromethorphan have included rare reports of fixed-drug eruptions.

Nervous system

Nervous system side effects of dextromethorphan have included drowsiness and dizziness. Other side effects such as excitation, mental confusion, and opiate-like respiratory depression have been rare and occurred at higher dosages. In some cases of abuse, patients experienced euphoria, hyperactivity, mania, and auditory and visual hallucinations.

Nervous system side effects of guaifenesin have occasionally included dizziness and headache.

Nervous system side effects of phenylephrine have included headache, dizziness, nervousness, restlessness, tremor, insomnia, convulsions, and central nervous system depression.

Psychiatric

Psychiatric side effects of phenylephrine have included hallucinations, fear, and anxiety.

Respiratory

Respiratory side effects of phenylephrine have included respiratory difficulty.

Dermatologic

Dermatologic side effects of guaifenesin have included rare reports of rash.

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