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Acetaminophen / Dextromethorphan / Guaifenesin / Phenylephrine Dosage

Medically reviewed by Drugs.com. Last updated on Sep 7, 2023.

Applies to the following strengths: 325 mg-10 mg-200 mg-5 mg; 325 mg-10 mg-200 mg-5 mg/15 mL; 650 mg-20 mg-400 mg-10 mg/20 mL; 325 mg-10 mg-100 mg-5 mg; 500 mg-20 mg-400 mg-10 mg; 325 mg-15 mg-200 mg-5 mg; 325 mg-10 mg-200 mg-5 mg/10 mL; 650 mg-20 mg-400 mg-10 mg; 162.5 mg-5 mg-100 mg-2.5 mg

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Cold Symptoms

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per tablet: 2 tablets every 4 hours
Maximum dose: 5 doses (10 tablets) per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per softgel: 2 softgels every 4 hours
Maximum dose: 6 doses (12 softgels) per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 10 mL liquid: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 15 mL liquid: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 20 mL liquid: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 30 mL liquid: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Usual Adult Dose for Influenza

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per tablet: 2 tablets every 4 hours
Maximum dose: 5 doses (10 tablets) per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per softgel: 2 softgels every 4 hours
Maximum dose: 6 doses (12 softgels) per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 10 mL liquid: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 15 mL liquid: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 20 mL liquid: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 30 mL liquid: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Usual Pediatric Dose for Cold Symptoms

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per tablet:
12 years and older: 2 tablets every 4 hours
Maximum dose: 5 doses (10 tablets) per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per softgel:
12 years and older: 2 softgels every 4 hours
Maximum dose: 6 doses (12 softgels) per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 10 mL liquid:
12 years and older: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

6 to under 12 years: 10 mL every 4 hours
Maximum dose: 5 doses per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 15 mL liquid:
12 years and older: 30 mL every 4 hours
6 to under 12 years: 15 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 20 mL liquid:
12 years and older: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 30 mL liquid:
12 years and older: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Usual Pediatric Dose for Influenza

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per tablet:
12 years and older: 2 tablets every 4 hours
Maximum dose: 5 doses (10 tablets) per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per softgel:
12 years and older: 2 softgels every 4 hours
Maximum dose: 6 doses (12 softgels) per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 10 mL liquid:
12 years and older: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

6 to under 12 years: 10 mL every 4 hours
Maximum dose: 5 doses per 24 hours

Acetaminophen 325 mg/ dextromethorphan 10 mg/ guaifenesin 200 mg/ phenylephrine 5 mg per 15 mL liquid:
12 years and older: 30 mL every 4 hours
6 to under 12 years: 15 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 20 mL liquid:
12 years and older: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ guaifenesin 400 mg/ phenylephrine 10 mg per 30 mL liquid:
12 years and older: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Use with caution.

Precautions

CONTRAINDICATIONS:


Safety and efficacy have not been established in patients younger than 6 years.

Dialysis

Data not available

Other Comments

Administration advice:


Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.