Acetaminophen / caffeine Side Effects

Not all side effects for acetaminophen / caffeine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to acetaminophen / caffeine: oral tablet, oral tablet disintegrating

Get emergency medical help if you have any of these signs of an allergic reaction while taking acetaminophen / caffeine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.

Stop using acetaminophen and caffeine and call your doctor at once if you have:

  • low fever with nausea, stomach pain, and loss of appetite;

  • dark urine, clay-colored stools; or

  • jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • sleep problems (insomnia); or

  • feeling nervous, irritable, or jittery.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to acetaminophen / caffeine: oral tablet, oral tablet disintegrating

Hepatic

Acetaminophen: Rare (less than 0.1%): Severe and sometimes fatal dose dependent hepatitis in alcoholic patients, hepatotoxicity increased during fasting, hepatotoxicity from chronic acetaminophen usage

Alcoholic patients may develop hepatotoxicity after even modest doses of acetaminophen. In healthy patients, approximately 15 grams of acetaminophen is necessary to deplete liver glutathione stores by 70% in a 70 kg person. However, hepatotoxicity has been reported following smaller doses. Glutathione concentrations may be repleted by the antidote N-acetylcysteine. One case report has suggested that hypothermia may also be beneficial in decreasing liver damage during overdose.

In a recent retrospective study of 306 patients admitted for acetaminophen overdose, 6.9% had severe liver injury but all recovered. None of the 306 patients died.

A 19 year old female developed hepatotoxicity, reactive plasmacytosis and agranulocytosis followed by a leukemoid reaction after acute acetaminophen toxicity.

Other

Caffeine: Rare (less than 0.1%): Fibrocystic breast disease

In one study of the effects of caffeine, 634 women with fibrocystic breast disease (compared to 1066 women without the disease), the occurrence of fibrocystic breast disease was positively associated with average daily consumption of caffeine. Women who consumed 31 to 250 mg/day of caffeine were reported to have a 1.5 times increase in odds to have the disease. Women who consumed over 500 mg/day of caffeine were reported to have a 2.3 times increase in odds.

Gastrointestinal

One study has suggested that acetaminophen may precipitate acute biliary pain and cholestasis. The mechanism of this effect may be related to inhibition of prostaglandin and alterations in the regulation of the sphincter of Oddi.

Acetaminophen: Rare (0.01% to 0.1%): Mostly seen in alcoholics and after overdose: Acute pancreatitis; Caffeine citrate: Very rare (less than 0.01%): Necrotizing enterocolitis in infants

Renal

Acetaminophen: Rare (less than 0.1%): Acute tubular necrosis, interstitial nephritis; these effects are most often observed after overdose or after chronic abuse (often with multiple analgesics), or in association with acetaminophen-related hepatotoxicity

Acute tubular necrosis usually occurs in conjunction with liver failure, but has been observed as an isolated finding in rare cases. A possible increase in the risk of renal cell carcinoma has been associated with chronic acetaminophen use as well.

A recent case control study of patients with end-stage renal disease suggested that long term consumption of acetaminophen may significantly increase the risk of end-stage renal disease particularly in patients taking more than two pills per day.

Hypersensitivity

Acetaminophen: Rare (less than 0.1%): Anaphylaxis, fixed drug eruptions

Hematologic

Acetaminophen: Rare (less than 0.1%): Thrombocytopenia, methemoglobinemia resulting in cyanosis in acute overdose

Dermatologic

Acetaminophen: Rare (0.01% 0.1%): Erythematous skin rashes, bullous erythema, purpura fulminans; Very rare (less than 0.01%): Potentially fatal skin reactions: Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP)

Respiratory

Acetaminophen: Very rare (less than 0.01%): Eosinophilic pneumonia

Cardiovascular

Acetaminophen: Very rare (less than 0.01%): Hypotension

Nervous system

Caffeine: Frequency not reported: Caffeinism (Caffeinism is a syndrome characterized by anxiety, restlessness, and sleep disorders similar to anxiety states), aggravation of PMS

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