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Prazosin Pregnancy and Breastfeeding Warnings

Prazosin is also known as: Minipress

Prazosin Pregnancy Warnings

Prazosin has been assigned to pregnancy category C by the FDA. Animal studies have shown evidence of decreased litter size after prazosin was administered at doses more than 225 times the maximum recommended dose in humans (on a per kg basis). No controlled data are available in human pregnancy, but studies in which prazosin was administered during human pregnancy show only maternal tachycardia and no teratogenic effects. Prazosin should only be given during pregnancy when benefit outweighs risk.

Use of prazosin combined with oxprenolol during human pregnancy has been reported. The population studied was 44 pregnant women, 25 of whom had severe hypertension, and 19 of whom had severe hypertension, edema, and proteinuria. There were three intrauterine deaths that were considered related to underlying diseases and not to drug therapy. One infant who suffered intrauterine growth retardation died postpartum after elective Cesarean section at 27 weeks gestation. This growth retardation was an expected finding given the underlying condition of the mother and the population studied. The overall fetal survival rate of 78% was considered acceptable relative to untreated hypertensive pregnancy fetal survival rates. In short, no definite causative connection has been made between adverse sequelae to the fetus and prazosin.

Prazosin Breastfeeding Warnings

The manufacturer states that small amounts of prazosin are excreted into human milk. The manufacturer recommends that caution be used when administering prazosin to nursing women.

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