Prazosin use while Breastfeeding

Drugs containing Prazosin: Minipress, Minizide

Prazosin Levels and Effects while Breastfeeding

Summary of Use during Lactation

Because little is available on the use of prazosin during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Drug Levels

Maternal Levels. The manufacturer reports that one mother was studied and excreted at most 3% of the dose into her breastmilk. No study details were presented.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Possible Effects on Lactation

Relevant published information in nursing mothers was not found as of the revision date. Prazosin does not affect serum prolactin concentration in patients with hypertension.[2][3] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

References

1. Schaefer C, Peters P, Miller RK, eds. Drugs during pregnancy and lactation. Treatment options and risk assessment, 2nd ed. Amsterdam; Boston: Elsevier Academic Press. 2007:685.

2. Barbieri C, Caldara R, Ferrari C et al. Metabolic effects of prazosin. Clin Pharmacol Ther. 1980;27:313-6. PMID: 6102000

3. Barbieri C, Ferrari C, Borzio M et al. Metabolic effects of chronic prazosin treatment. Horm Metab Res. 1980;12:331-4. PMID: 6105121

Prazosin Identification

Substance Name

Prazosin

CAS Registry Number

19216-56-9

Drug Class

  • Adrenergic alpha-Antagonists
  • Antihypertensive Agents

Administrative Information

LactMed Record Number

744

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

See Also...

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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