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Pimozide Pregnancy and Breastfeeding Warnings

Pimozide is also known as: Orap

Pimozide Pregnancy Warnings

Pimozide has been assigned to pregnancy category C by the FDA. Animal studies have revealed prolonged estrus cycles, decreased numbers of pregnancies, retarded development of fetuses, dose related maternal toxicity, mortality, decreased weight gain, and embryotoxicity including increased resorptions. There are no controlled data in human pregnancy. Neonates exposed to antipsychotic drugs during the third trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms following delivery. There have been reports of agitation, hypertonia, hypotonia, tremor, somnolence, respiratory distress and feeding disorder in these neonates. These complications have varied in severity; while in some cases symptoms have been self-limited, in other cases neonates have required intensive care unit support and prolonged hospitalization. Pimozide is only recommended for use during pregnancy when there are no alternatives and benefit outweigh risk.

Pimozide Breastfeeding Warnings

There are no data on the excretion of pimozide into human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions due to pimozide in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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