Class: Antibiotic, Fluoroquinolone, Ophthalmic
- Ophthalmic solution 0.3%
- Ophthalmic solution 0.5%
Antibacterial action results from inhibition of DNA gyrase and topoisomerase IV.
C max is less than 5 ng/mL.
Indications and Usage
Treatment of bacterial conjunctivitis caused by susceptible organisms.
None well documented.
Dosage and AdministrationAdults and Children 1 y of age and older Zymar
Ophthalmic Days 1 and 2, instill 1 drop in affected eye(s) every 2 h while awake, up to 8 times/day. Days 3 through 7, instill 1 drop up to 4 times daily while awake.Zymaxid
Ophthalmic Day 1, instill 1 drop every 2 h in affected eye(s) while awake, up to 8 times/day. Days 2 through 7, instill 1 drop 2 to 4 times/day while awake.
- For topical instillation into eye(s) only. Do not introduce directly into the anterior chamber of the eye.
- Have patient tilt head back, pull lower lid out to make pocket, and instill medication into conjunctival sac. Have patient close eyes and apply light finger pressure to bridge of nose for 1 to 2 min. Advise patient not to blink or rub eyes.
- If using other topical ophthalmic drugs, separate each medication by at least 5 min.
Store at 59° to 77°F. Protect from freezing.
None well documented.
Headache (1% to 4%).
Conjunctival irritation, increased lacrimation, keratitis, papillary conjunctivitis (5% to 10%); chemosis, conjunctival hemorrhage, dry eye, eye discharge, eye irritation, eye pain, eyelid edema, red eye, reduced visual acuity (1% to 4%); worsening of conjunctivitis (1% or more).
Taste perversion (1% to 4%); dysgeusia (1% or more).
Monitor patient for signs and symptoms of ocular adverse reactions (eg, burning, stinging pain, irritation) and improvement in conjunctivitis. Notify health care provider if conjunctivitis is not improving or is worsening or if intolerable adverse reactions occur.
Category C .
Safety and efficacy not established in patients younger than 1 yr of age.
Use of antibiotics may result in bacterial or fungal overgrowth.
Patients should not wear contact lenses.
- Remind patients not to wear contact lenses if signs and symptoms of bacterial conjunctivitis occur.
- Teach patient proper technique for instilling eye drops: wash hands; do not allow dropper to touch eye. Tilt head back and look up; pull lower eyelid down; instill prescribed number of drops. Close eye for 1 to 2 min and apply gentle pressure to bridge of nose. Do not rub eye.
- Advise patient that if more than 1 topical ophthalmic drug is being used to administer the drugs at least 5 min apart.
- Advise patient to inform health care provider if ocular adverse reactions occur and become bothersome or if infection is not improving.
- Instruct patients to avoid contaminating the applicator tip with material from the eye, finger, or other source.
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