Cetirizine Hydrochloride / Pseudoephedrine Hydrochloride
Pronunciation: se-TIR-i-zeen HYE-droe-KLOR-ide/SOO-doe-e-FED-rin HYE-droe-KLOR-ide
Class: Upper respiratory combinations
Zyrtec-D 12 Hour
- Tablets, extended-release cetirizine hydrochloride 5 mg/pseudoephedrine hydrochloride 120 mg
Indications and Usage
Relief of nasal and non-nasal symptoms associated with seasonal or perennial allergic rhinitis.
Narrow-angle glaucoma; urinary retention; severe hypertension; severe coronary artery disease; patients receiving MAOIs or within 14 days of stopping such treatment; hypersensitivity to any component of the product, adrenergic agents, or other drugs of similar chemical structure; manifestations of patient idiosyncrasy to adrenergic agents, including arrhythmias, dizziness, insomnia, tremor, or weakness.
Dosage and AdministrationAdults and Children 12 yr of age and older Maximum dose
Cetirizine 20 mg/day; pseudoephedrine 240 mg/dayUsual dosage
One 12-h tablet (cetirizine 5 mg/pseudoephedrine 120 mg) by mouth twice a day.Hepatic or Renal Function Impairment
Adults and Children 12 yr of age and older
PO One 12-h tablet (cetirizine 5 mg/pseudoephedrine 120 mg) once daily in patients on hemodialysis (CrCl less than 7 mL/min), with hepatic function impairment, or with decreased renal function (CrCl 11 to 31 mL/min).
- May be taken with or without food.
- Patients must swallow ER tablet whole and should not break or chew.
Store at 68° to 77°F.
Drug InteractionsAntihypertensive agents that interfere with sympathetic activity (eg, mecamylamine, methyldopa, reserpine)
Antihypertensive effects of these agents may be reduced.Digitalis
Increased ectopic pacemaker activity.MAOIs (eg, phenelzine)
Coadministration is contraindicated with pseudoephedrine and for 14 days after stopping the MAOI.Sympathomimetic amines
Additive or potentiated effects on the CV system.
Laboratory Test Interactions
Positive reactions to skin tests may be prevented or diminished.
Insomnia (4%); fatigue, somnolence (2%); dizziness (1%).
Pharyngitis (2%); epistaxis (1%).
Dry mouth (4%).
Accidental injury (1%).
Category C .
Both ingredients are excreted in breast milk.
Safety and efficacy not established in children younger than 12 yr of age.
Use with caution, usually starting at the low end of the dosage range, because of the greater frequency of decreased hepatic, renal, or cardiac function, and concomitant diseases or other drug therapy.
Special Risk Patients
Use with caution in patients with diabetes mellitus, hypertension, hyperthyroidism, increased IOP, ischemic heart disease, prostatic hypertrophy, or renal function impairment.
Cognitive and motor impairment
Caution patients about operating potentially hazardous machinery (eg, driving) until they know whether the drug impairs their ability. Avoid use of alcohol.
Drowsiness, irritability, somnolence.Pseudoephedrine
Anxiety, cardiac arrhythmias, circulatory collapse, coma, convulsions, difficulty in micturition, giddiness, headache, insomnia, muscular weakness, nausea, palpitations, precordial pain, respiratory failure, restlessness, sweating, tachycardia, tenseness, thirst, toxic psychosis with delusions and hallucinations, vomiting.
- Instruct patient regarding how to store, administer, and dispose of outdated medication.
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