Skip to main content

Prediction Model for Invasive Breast Cancer Improved With Additional Risk Factors

Medically reviewed by Carmen Pope, BPharm. Last updated on Dec 6, 2023.

By Lori Solomon HealthDay Reporter

WEDNESDAY, Dec. 6, 2023 -- The inclusion of additional risk factors improves the predictive value of the Breast Cancer Surveillance Consortium (BCSC) version 2 model for identifying women at risk for invasive breast cancer, according to a study published online Nov. 17 in the Journal of Clinical Oncology.

Charlotte C. Gard, Ph.D., from New Mexico State University in Las Cruces, and colleagues examined the effectiveness of expanding the BCSC version 2 model of invasive breast cancer risk to include body mass index (BMI), extended family history of breast cancer, and age at first live birth. The analysis included 1,455,493 women (aged 35 to 79 years) without a history of breast cancer.

The researchers found that during 7.3 years of follow-up, 30,266 women were diagnosed with invasive breast cancer. The BCSC version 3 model had an expected-to-observed ratio of 1.03 and an area under the receiver operating characteristic curve of 0.646 for five-year risk. Discrimination of the version 3 model improved most in Asian, White, and Black women compared with version 2. The true-positive rate in women with BMI of 30.0 to 34.9 kg/m2 and an estimated five-year risk of ≥3 percent increased from 10.0 percent (version 2) to 19.8 percent (version 3), with improvement greater among women with a BMI of ≥35 kg/m2.

"The updated BCSC model can help provide context for discussions between patients and their providers when a woman learns that she has dense breasts on her mammogram," coauthor Jeffrey Tice, M.D., from University of California in San Francisco, said in a statement.

Abstract/Full Text (subscription or payment may be required)

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2024 HealthDay. All rights reserved.

Posted December 2023

Read this next

Physical Activity in Middle Age Improves Health Among Women

FRIDAY, May 3, 2024 -- Adherence to physical activity guidelines during middle age appears to improve health-related quality of life among women, according to a study...

Diabetes Increases Risk for Functional Limitations in Older Adults

FRIDAY, May 3, 2024 -- Older adults with diabetes are more likely to develop functional limitations than adults without diabetes, according to a study published online April 16 in...

2020 Cancer Screening Rates Low at Federally Qualified Health Centers

FRIDAY, May 3, 2024 -- In 2020, there were major gaps in screening clients at federally qualified health centers (FQHCs) for various types of cancer when compared with the general...

More news resources

Subscribe to our newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.