High Predictability for Measles Antibody Dynamics Discernible From Birth
By Elana Gotkine HealthDay Reporter
MONDAY, May 13, 2024 -- At the individual level, there is high predictability for measles antibody dynamics from birth, according to a study published online May 13 in Nature Microbiology.
Wei Wang, from the Key Laboratory of Public Health Safety in Shanghai, and colleagues reconstructed antibody trajectories from birth by combining serological data from 1,505 individuals (aged 0 to 12 years) in a mother-infant cohort and in a child cohort from Hunan, China, with empirical models. Participants had complete measles vaccination records and antibody measurements.
The researchers found that across a population, measles antibody evolution was highly heterogeneous, and at the individual level, antibody evolution was strongly predictive from birth, including following vaccination. The odds of primary vaccine failure were increased 2.56-fold in association with cesarean births.
"With a C-section birth, children aren't exposed to the mother's microbiome in the same way as with a vaginal birth," joint senior author Henrik Salje, Ph.D., from the University of Cambridge in the United Kingdom, said in a statement. "We think this means they take longer to catch up in developing their gut microbiome, and with it, the ability of the immune system to be primed by vaccines against diseases, including measles."
One author disclosed ties to the pharmaceutical industry.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted May 2024
Read this next
American College of Obstetricians and Gynecologists, May 17-19
The annual meeting of the American College of Obstetricians and Gynecologists was held from May 17 to 19 in San Francisco and was attended by more than 4,000 clinicians...
Epidural Analgesia Linked to Decline in Severe Maternal Morbidity
FRIDAY, May 24, 2024 -- Epidural analgesia during labor is associated with a reduction in severe maternal morbidity (SMM), according to a study published online May 22 in The...
CDC: Decrease in Maternal Mortality Rates Seen in 2022
THURSDAY, May 2, 2024 -- In 2022, there was a decrease in maternal mortality rates, according to a report published in the May Health E-Stats, a publication of the U.S. Centers...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.