GWAS Identifies 108 Independent Risk Loci for Kidney Cancer
By Elana Gotkine HealthDay Reporter
THURSDAY, May 2, 2024 -- A genome-wide association study meta-analysis, published online April 26 in Nature Genetics, has identified 63 susceptibility regions containing 108 independent risk loci for kidney cancer.
Mark P. Purdue, Ph.D., from the National Cancer Institute in Rockville, Maryland, and colleagues conducted a multi-ancestry genome-wide association study meta-analysis of kidney cancer involving 29,020 cases and 835,670 controls to identify susceptibility regions.
The researchers identified 63 susceptibility regions, of which 50 were novel, which included 108 independent risk loci. In subtype-stratified analyses, 52 regions with 78 loci were associated with clear cell renal cell carcinoma (RCC) and six regions with seven loci were associated with papillary RCC. A variant common in individuals of African ancestry, located in the 3' untranslated region of VHL, yielded a nearly threefold increased risk for clear cell RCC (odds ratio, 2.72). In analyses of cis-expression quantitative trait loci, 34 regions with 48 variants indicated 83 candidate genes. The importance of hypoxia-related mechanisms in kidney cancer was underscored by enrichment of hypoxia-induced factor-binding sites. These results enabled generation of a validated polygenic risk score, which had an estimated area under the curve of 0.65 among individuals of European ancestry (0.74 in a model including risk factors).
"Our study demonstrates genetic factors common to different histologic subtypes and at the same time, defines subtype-specific variants, which in turn could lead to new avenues for research," the authors write.
Several authors disclosed ties to the biopharmaceutical and medical technology industries.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted May 2024
Read this next
BMI Cutoff of 30 for Obesity May Be Too High for Middle-Aged, Older Adults
FRIDAY, May 31, 2024 -- The optimal body mass index (BMI) cutoff point appears to be 27 kg/m2 for detecting obesity in middle-aged and older adults, according to a study presented...
Emergency Inguinal Hernia Surgery Rates Increased With Lower Country Income
FRIDAY, May 31, 2024 -- For patients undergoing inguinal hernia surgery, emergency surgery rates increase from high- to low-income countries, according to a study published online...
Maternal Serum Alpha-Fetoprotein Levels Higher in Black Than White Women
FRIDAY, May 31, 2024 -- Maternal serum alpha-fetoprotein (AFP) levels are higher in Black than White pregnant women, supporting the use of accounting for these differences in...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.