Cell-Free DNA Methylation Liquid Biopsy Discriminates Ovarian Cancer
Medically reviewed by Drugs.com.
By Elana Gotkine HealthDay Reporter
THURSDAY, Oct. 19, 2023 -- A classifier based on cell-free DNA (cfDNA) methylation liquid biopsy can discriminate high-grade serous ovarian carcinoma (HGSOC) from benign masses, according to a study published online Oct. 9 in Clinical Cancer Research.
David N. Buckley, from the University of Southern California in Los Angeles, and colleagues developed a cfDNA methylation liquid biopsy for risk assessment of early-stage HGSOC. Reduced representation bisulfite sequencing was performed to identify differentially methylated regions (DMRs) between HGSOC and normal ovarian and fallopian tube tissues. Hybridization probe capture was then performed for 1,677 DMRs; to discriminate HGSOC from benign masses, a classifier (OvaPrint) was constructed on an independent set of cfDNA samples. The generalizability of OvaPrint was assessed in a series of non-HGSOC epithelial ovarian cancers, including low-grade and borderline samples. Overall, 372 samples (59 tissue and 313 plasma) were analyzed.
The researchers found that for discriminating HGSOC from benign masses, OvaPrint achieved overall accuracy of 91 percent and had a positive predictive value and negative predictive value of 95 and 88 percent, respectively, surpassing other commercial tests. For non-HGSOC epithelial ovarian cancer, OvaPrint was less sensitive, although it may have potential utility for identifying low-grade and borderline tumors with higher malignant potential.
"Early detection saves lives," coauthor Bodour Salhia, Ph.D., also from the University of Southern California, said in a statement. "If we can accurately identify early-stage ovarian cancer, we can change the outcome of the disease and really crank up survival rates."
Two authors disclosed ties to CpG Diagnostics; one author disclosed ties to Aspira Women’s Health.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted October 2023
Read this next
Disparities Seen in Cancer Treatment Delivery at Minority-Serving Hospitals
TUESDAY, May 28, 2024 -- There are systemic disparities in definitive cancer treatment delivery at minority-serving hospitals (MSHs) versus non-MSHs, according to a study...
ASCO: Conjugated Equine Estrogen May Increase Risk for Ovarian Cancer
TUESDAY, May 28, 2024 -- Conjugated equine estrogen (CEE) taken alone for menopause may increase the risk for developing and dying from ovarian cancer, according to a study...
One in Nine U.S. Children Have Ever Been Diagnosed With ADHD
THURSDAY, May 23, 2024 -- Diagnoses of attention-deficit/hyperactivity disorder (ADHD) in U.S. children continue to increase, with approximately one in nine having ever received a...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.