Benefit of ICD Attenuated in CKD Patients Receiving Cardiac Resynchronization
Medically reviewed by Drugs.com.
By Elana Gotkine HealthDay Reporter
MONDAY, Sept. 25, 2023 -- For patients with advanced chronic kidney disease (CKD) receiving cardiac resynchronization therapy (CRT), the benefit of an implantable cardioverter defibrillator (ICD) may be attenuated, according to a study published online Aug. 23 in Frontiers in Cardiovascular Medicine.
Ido Goldenberg, M.D., from the University of Rochester Medical Center in New York, and colleagues examined whether patients with CKD who are CRT recipients derive less benefit from an ICD due to the competing risk of dying prior to experiencing an arrhythmia. The study population included 1,015 patients receiving CRT with a defibrillator device for primary prevention of sudden cardiac death. The cohort was divided based on CKD stage: stage 1 to 3a KD ([S1-S3a]KD) and stage 3b to 5 KD ([S3b-S5]KD).
The researchers found that the cumulative incidence of the primary end point of any ventricular tachycardia (VT) or ventricular fibrillation (VF) was 23.5 and 12.6 percent in those with (S1-S3a)KD and (S3b-S5)KD, respectively. The incidence of death without any VT/VF was 6.6 and 21.6 percent in patients with (S1-S3a)KD and (S3b-S5)KD, respectively. Compared with those with (S1-S3a)KD, patients with (S3b-S5)KD had a significantly lower risk for experiencing any VT/VF (hazard ratio, 0.56). Patients with (S3b-S5)KD had a significantly higher risk for death without any VT/VF compared with those with (S1-S3a)KD after two years of follow-up (hazard ratio, 4.63).
"The results of this study suggest that due to their comparatively high nonarrhythmic mortality rate and lower rate of ventricular arrhythmias, CRT recipients with advanced CKD do not appear to attain the same benefit from a primary prevention ICD as those patients without advanced CKD," the authors write.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted September 2023
Read this next
Cardiovascular, Kidney, and Metabolic Syndrome Highly Prevalent in the U.S.
FRIDAY, May 10, 2024 -- Cardiovascular, kidney, and metabolic (CKM) syndrome is highly prevalent in the United States, with more than 90 percent of adults meeting the criteria for...
SGLT2 Inhibitors Improve Outcomes in Patients With Diabetes Plus Kidney Disease
THURSDAY, May 2, 2024 -- Use of sodium–glucose cotransporter-2 inhibitors (SGLT2is) is associated with a substantially lower risk for dialysis and cardiovascular disease in...
Leukocyte Glucose Index, Arteriovenous Fistula Failure Linked in ESKD
MONDAY, April 22, 2024 -- For patients with end-stage kidney disease (ESKD), a high preoperative leukocyte glucose index (LGI) is associated with arteriovenous fistula (AVF)...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.