Bariatric-Metabolic Surgery Effective for Nonalcoholic Steatohepatitis Treatment
Medically reviewed by Drugs.com.
By Elana Gotkine HealthDay Reporter
WEDNESDAY, May 3, 2023 -- For patients with nonalcoholic steatohepatitis (NASH), bariatric-metabolic surgery is more effective than lifestyle modification plus best medical care, according to a study published online April 20 in The Lancet.
Ornella Verrastro, Ph.D., from the Università Cattolica del Sacro Cuore in Rome, and colleagues conducted a multicenter randomized trial involving patients aged 25 to 70 years with obesity, with or without type 2 diabetes, with histologically confirmed NASH. Participants were randomly assigned to lifestyle modification plus best medical care, Roux-en-Y gastric bypass, or sleeve gastrectomy (96 patients to each group).
The researchers found that the percentage of patients who met the primary end point of histological resolution of NASH without worsening of fibrosis at one-year follow-up was significantly higher in the Roux-en-Y gastric bypass and sleeve gastrectomy groups compared with the lifestyle modification group (56 and 57 percent, respectively, versus 16 percent) in the intention-to-treat analysis. In the per-protocol analysis, the primary end point was met by 70, 70, and 19 percent, respectively. There were no reports of deaths or life-threatening complications. Ten participants who had bariatric-metabolic surgery had severe adverse events; they did not require reoperations.
"The presence of NASH predicts a significant risk of complications and mortality in people with severe obesity and type 2 diabetes," a coauthor said in a statement. "The results of this study provide a compelling case for prioritization of metabolic surgery in this patient population."
Two authors disclosed financial ties to the pharmaceutical industry.
Editorial (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted May 2023
Read this next
Semaglutide Alleviates Metabolic-Linked Liver Disease in People With HIV
TUESDAY, April 30, 2024 -- For people with HIV (PWH), semaglutide is effective for metabolic dysfunction-associated steatotic liver disease (MASLD), according to a research letter...
ACP: Time-Restricted Eating May Not Aid Weight Loss, Glycemic Measures
TUESDAY, April 23, 2024 -- Time-restricted eating (TRE) is not associated with weight loss or glycemic improvements compared with a usual eating pattern (UEP) when calories are...
Hypoglossal Nerve Stimulation Aids Obstructive Sleep Apnea
THURSDAY, April 18, 2024 -- Hypoglossal nerve stimulation (HGNS) helps to reduce obstructive sleep apnea (OSA) but has a decreased response in some patients, according to a study...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.