Portrazza

Generic name: necitumumab [ NE-si-TOOM-oo-mab ]
Drug class: EGFR inhibitors

Medically reviewed by Drugs.com on Dec 26, 2023. Written by Cerner Multum.

What is Portrazza?

Portrazza is a monoclonal antibody that blocks a certain protein in the body that can affect tumor cell growth. Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage.

Portrazza is used to treat a certain type of non-small cell lung cancer. This medicine is usually given in combination with other cancer medications.

Portrazza may also be used for purposes not listed in this medication guide.

Portrazza side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your caregiver right away if you feel chilled or feverish, or if you have trouble breathing.

Portrazza may cause serious side effects. Call your doctor at once if you have:

• acne-like skin rash;

• thickened skin or a hard lump where the medicine was injected;

• slow heart rate, weak pulse, fainting, slow breathing (breathing may stop);

• chest pain or pressure, pain spreading to your jaw or shoulder;

• signs of a blood clot--sudden numbness or weakness, problems with vision or speech, sudden cough, wheezing, coughing up blood, pain or swelling in an arm or leg; or

• symptoms of an electrolyte imbalance--numbness or tingling, irregular heartbeats, muscle tightness, tremors, muscle weakness or limp feeling, leg cramps, increased thirst or urination, behavior changes, seizure (convulsions).

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of Portrazza may include:

• vomiting, diarrhea;

• skin rash; or

• low levels of magnesium in your blood.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Rybrevant, methotrexate, Keytruda, pembrolizumab, Avastin, cisplatin, Tagrisso

Warnings

Portrazza can cause your electrolytes to become unbalanced. This can lead to serious heart problems, including cardiac arrest. You will need frequent blood tests to check your electrolytes (calcium, potassium, and magnesium).

Before taking this medicine

You should not be treated with Portrazza if you are allergic to it.

To make sure Portrazza is safe for you, tell your doctor if you have:

• coronary artery disease (hardened arteries);

• high blood pressure;

• chronic obstructive pulmonary disease (COPD);

• an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or

• a history of heart attack or stroke.

Using Portrazza during pregnancy could harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Use effective birth control to prevent pregnancy while you are using Portrazza and for at least 3 months after your last dose.

It is not known whether necitumumab passes into breast milk or if it could harm a nursing baby. Do not breast-feed while you are being treated with necitumumab, and for at least 3 months after your last dose.

How is Portrazza given?

Portrazza is injected into a vein through an IV. A healthcare provider will give you this injection. This medicine must be injected slowly, and the IV infusion can take at least 1 hour to complete.

Portrazza is given in a 21-day treatment cycle. You may need to use the medicine only on days 1 and 8 of each cycle. Your doctor will determine how long to treat you with this medicine.

You may be given medication to prevent certain side effects while you are receiving Portrazza.

Portrazza can cause your electrolytes to become unbalanced. This can lead to serious heart problems, including cardiac arrest. You will need frequent blood tests to check your electrolytes (calcium, potassium, and magnesium).

Your doctor may recommend that you take mineral supplements to keep your electrolytes from getting too low. Follow your doctor's dosing instructions very carefully.

Portrazza can have long-lasting effects on your body. You may need frequent medical tests for at least 8 weeks after you stop using this medicine.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Portrazza.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include headache, nausea, or vomiting.

What should I avoid while receiving Portrazza?

Avoid exposure to sunlight or tanning beds. Portrazza can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What other drugs will affect Portrazza?

Other drugs may interact with necitumumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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