glutamine

Generic Name: glutamine (GLOO ta meen)
Brand Name: GlutaSolve, NutreStore, SYMPT-X G.I., SYMPT-X Glutamine

What is glutamine?

Glutamine is an amino acid that affect the processes of growth and function of cells in the stomach and intestines.

Glutamine is a medical food product that is used to supplement dietary sources of glutamine, to treat a glutamine deficiency, or to treat a loss of glutamine caused by injury or illness.

Glutamine is also used in combination with human growth hormone to treat short bowel syndrome.

Glutamine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about glutamine?

Before you take glutamine, tell your doctor if you have liver or kidney disease.

The number of times per day you take glutamine depends on the reason you are using it. Always follow your doctor's instructions.

Take glutamine oral powder with a meal or snack unless directed otherwise.

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Take glutamine tablets on an empty stomach, at least 1 hour before or 2 hours after a meal.

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using glutamine.

Do not pour dry glutamine powder directly into a tube feeding formula. Always mix the powder with water and infuse it directly into the feeding tube using a syringe.

Glutamine may be only part of a complete program of treatment that may also include a special diet, tube feedings, and IV fluids. It is very important to follow the diet and medication plan created for you by your doctor or nutrition counselor.

What should I discuss with my health care provider before taking glutamine?

Before you take glutamine, tell your doctor if you have liver or kidney disease. You may need a dose adjustment or special tests to safely use this medication.

FDA pregnancy category C. It is not known whether glutamine is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether glutamine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take glutamine?

Use this medication as directed on the label, or as your doctor has prescribed. Do not use the medication in larger amounts or for longer than recommended.

When treating short bowel syndrome, you may need to take glutamine 6 times per day for up to 16 weeks.

The number of times per day you take glutamine depends on the reason you are using it. Always follow your doctor's instructions.

Take glutamine oral powder with a meal or snack unless directed otherwise.

Take glutamine tablets on an empty stomach, at least 1 hour before or 2 hours after a meal.

Dissolve your dose of glutamine oral powder in at least 8 ounces of hot or cold liquid. You may also mix the powder with a soft food such as pudding, applesauce, or yogurt. Stir this mixture and use all of it right away.

Do not pour dry glutamine powder directly into a tube feeding formula. Always mix the powder with water and infuse it directly into the feeding tube using a syringe.

To be sure this medication is not causing harmful effects, your kidney and liver function may need to be checked with blood or urine tests on a regular basis. Do not miss any scheduled appointments.

Glutamine may be only part of a complete program of treatment that may also include a special diet, tube feedings, and IV fluids. It is very important to follow the diet and medication plan created for you by your doctor or nutrition counselor.

Store glutamine at room temperature away from moisture and heat. Keep each dose of the oral powder in its packet until you are ready to use the medication.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

An overdose of glutamine is not expected to produce life-threatening symptoms.

What should I avoid while taking glutamine?

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using glutamine.

Glutamine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • chest pain;

  • hearing problems; or

  • signs of infection such as fever, chills, sore throat, flu symptoms, mouth sores, unusual weakness.

Less serious side effects may include:

  • nausea, vomiting, stomach pain, gas;

  • dry mouth, runny nose;

  • swelling in your hands or feet;

  • muscle or joint pain, back pain;

  • headache, dizziness, tired feeling;

  • mild skin rash or itching; or

  • increased sweating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Glutamine dosing information

Usual Adult Dose for Dietary Supplement:

Average Dose: 10 g orally 3 times per day

Dosing range: 5 g to 30 g orally per day

Usual Adult Dose for Short Bowel Syndrome:

Oral: 5 g orally 6 times per day at 2 to 3 hour intervals, with meals or snacks, while awake, for up to 16 weeks; to be used in combination with growth hormone and nutritional support.

Usual Adult Dose for Sickle Cell Anemia:

In a clinical study of 7 patients after 4 weeks of therapy with glutamine at 30 g orally per day, there was clinical benefit in reducing the oxidative susceptibility of sickle red blood cells.

Usual Pediatric Dose for Sickle Cell Anemia:

In a clinical study of 27 children (5.2 to 17.9 years old) after 24 weeks of therapy with glutamine at 600 mg/kg/day orally there was clinical benefit seen in resting energy expenditure and improvement in nutritional parameters.

What other drugs will affect glutamine?

There may be other drugs that can interact with glutamine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about glutamine.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 1.06. Revision Date: 2010-12-15, 5:01:39 PM.

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