Capivasertib

Generic name: capivasertib [ kap-EYE-va-SER-tib ]
Brand name: Truqap
Dosage form: oral tablet (160 mg; 200 mg)
Drug class: Multikinase inhibitors

Medically reviewed by Drugs.com on Feb 1, 2024. Written by Cerner Multum.

What is capivasertib?

Capivasertib is used in combination with fulvestrant to treat hormone-related breast cancer.

Capivasertib is used when the cancer has progressed, spread to other parts of the body (metastatic), or after other treatments did not work or stopped working.

Your doctor will make sure you have the correct tumor type to be treated with capivasertib.

Capivasertib may also be used for purposes not listed in this medication guide.

Capivasertib side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Capivasertib may cause serious side effects. Call your doctor at once if you have:

• redness, new or worsening rash, or blisters on the palms of your hands or the soles of your feet;

• severe stomach pain, diarrhea that is watery or bloody;

• high blood sugar--increased urination, dry mouth, fruity breath odor, nausea, vomiting, appetite or weight changes; or

• dehydration--dizziness, confusion, feeling very thirsty, less urination.

Your cancer treatments may change, be delayed or permanently discontinued if you have certain side effects.

Common side effects of capivasertib may include:

• nausea, vomiting, or diarrhea;

• abnormal blood tests;

• blisters or ulcers in your mouth, red or swollen gums, trouble swallowing; or

• tiredness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Kisqali, Ibrance, Arimidex, Femara, Xeloda, Herceptin, Verzenio

Warnings

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

Before taking this medicine

You should not use capivasertib if you are allergic to it.

Tell your doctor if you have or ever had:

• high blood sugar levels, type 1 or type 2 diabetes, if you use insulin;

• rash or other skin problems; or

• liver disease.

Capivasertib can harm an unborn baby if the mother or the father is using capivasertib.

• If you are a woman, you will need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 1 month after your last dose.

• If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 4 months after your last dose.

• Tell your doctor right away if a pregnancy occurs.

Do not breastfeed while using this medicine.

How should I take capivasertib?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Your doctor will perform tests to make sure capivasertib is the right treatment for you.

Capivasertib is taken in a 7-day treatment cycle. You will take the medicine only on certain days. Your doctor will determine your treatment cycle.

Capivasertib is usually taken twice per day (about 12 hours apart) with or without food. Take the medicine at the same time each day.

Swallow the tablet whole with water and do not crush, chew, or break it. Do not use a tablet that is damaged in any way.

Your blood sugar and skin will need to be checked on a regular basis, and you may need other medical tests. Your cancer treatments may be delayed based on the results.

Call your doctor if you have severe diarrhea. Drink plenty of liquids while you are taking capivasertib.

You may be given other medications for your treatment or to help prevent serious side effects. Keep taking these medicines for as long as your doctor has prescribed.

If you vomit shortly after taking capivasertib, do not take another dose. Take your next dose as scheduled.

Keep the medicine in the original container and store at room temperature away from moisture and heat.

Capivasertib dosing information

Usual Adult Dose for Breast Cancer:

400 mg orally twice a day for 4 days, followed by 3 days off
Duration of therapy: Until disease progression or unacceptable toxicity

Comments:
-This drug should be administered in combination with fulvestrant; consult the manufacturer product information for fulvestrant for dosing information.
-Each dose of this drug should be given approximately 12 hours apart.
-Patients should be selected for treatment based on the presence of one or more of the following genetic alterations in tumor tissue: PIK3CA/AKT1/PTEN.
-In premenopausal and perimenopausal women, a luteinizing hormone-releasing hormone (LHRH) agonist should be administered according to current clinical practice standards.
-In men, consider administering a LHRH agonist according to current clinical practice standards.

Use: In combination with fulvestrant, for the treatment of hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, locally advanced or metastatic breast cancer with one or more PIK3CA/AKT1/PTEN-alteration as detected by an FDA-approved test following progression on at least one endocrine-based regimen in the metastatic setting or recurrence on or within 12 months of completing adjuvant therapy.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if you are more than 4 hours late for the dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking capivasertib?

Grapefruit may interact with capivasertib and cause side effects. Avoid consuming grapefruit products.

What other drugs will affect capivasertib?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Other drugs may affect capivasertib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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