Dyclonine Hydrochloride

Class: Local Anesthetics
ATC Class: R02AD04
VA Class: DE700
CAS Number: 536-43-6
Brands: Sucrets, Sucrets Complete

Introduction

Local anesthetic.100 a b

Uses for Dyclonine Hydrochloride

Oral/Throat Analgesia/Anesthesia

Self-medication for the short-term relief of minor sore throat pain and mouth and gum irritation.a b

Slideshow: 2014 Update: First Time Brand-to-Generic Switches

In fixed combination with menthol as self-medication for temporary relief of occasional minor irritation, pain, or soreness of mouth or throat, and for cough associated with a cold or inhaled irritants.100

Local Anesthesia

Has been used as a local anesthetic agent prior to laryngoscopy, bronchoscopy, esophagoscopy, or endotracheal intubation.a However, oral solutions no longer are commercially available in the US.a

Dyclonine Hydrochloride Dosage and Administration

Administration

Oral Administration

Administer orally as a lozenge.100 a b

Allow the lozenge to slowly dissolve in the mouth; do not bite or chew it.100 a b

Dosage

Pediatric Patients

Oral/Throat Pain
Oral

Children ≥2 years of age: 1 lozenge (1.2, 2, or 3 mg); repeat after 2 hours if necessary.100 a

Adults

Oral/Throat Pain
Oral

1 lozenge (1.2, 2, or 3 mg); repeat after 2 hours if necessary.100 a b

Prescribing Limits

Pediatric Patients

Oral/Throat Pain
Oral

Children ≥2 years of age: Maximum 10 lozenges daily.a b Not for self-medication of sore throat for >2 days or sore mouth >7 days.100 a

Adults

Oral/Throat Pain
Oral

Maximum 10 lozenges daily.a b Not for self-medication of sore throat for >2 days or sore mouth >7 days.100 a b

Special Populations

No special population dosage recommendations at this time.a

Cautions for Dyclonine Hydrochloride

Contraindications

  • Known hypersensitivity to dyclonine or any ingredient in the formulation.a

Warnings/Precautions

Sensitivity Reactions

Allergic Reactions

Use with caution in patients with a known allergy to dyclonine.a

Sensitization and allergic reactions are infrequent.a Possible hypersensitivity reactions to anesthetics may manifest as cutaneous lesions with delayed onset, urticaria, swelling, and edema.a

General Precautions

Systemic Effects

Systemic (e.g., CNS, cardiovascular) effects possible with excessive dosage or rapid absorption of dyclonine.a

Adverse CNS effects may include excitation and/or depression, nervousness, dizziness, blurred vision, or tremors followed by seizures, unconsciousness, drowsiness, and possibly respiratory arrest.a

Adverse cardiovascular effects may include myocardial depression, hypotension, bradycardia, and cardiac arrest.a

Patient Monitoring

If sore throat is severe or persistent (e.g., >2 days) or occurs with or is followed by a high fever, persistent headache, rash, swelling, irritation, and nausea, discontinue the drug and consult a clinician.100 a b

If sore mouth symptoms do not improve after 7 days, discontinue the drug and consult a clinician.100 b

Infection or Trauma

Use with extreme caution in areas with traumatized mucosa and/or when sepsis is present in the region of intended application.a

Use of Fixed Combination

When used in fixed combination with other agents, consider the cautions, precautions, and contraindications associated with the concomitant agents.

Specific Populations

Pregnancy

Safety has not been established in pregnant women.a Manufacturers state that pregnant women should consult a clinician prior to use.100 b

Lactation

Manufacturers state that nursing women should consult a clinician prior to use.100 b

Pediatric Use

Safety of dyclonine lozenges not established in children <2 years of age; consult a clinician or dentist prior to use in such patients.100 b

Common Adverse Effects

Irritation,a stinging.a

Dyclonine Hydrochloride Pharmacokinetics

Absorption

Onset

Following topical application of a 0.5 or 1% solution of dyclonine (both no longer commercially available in the US) to mucous membranes, local anesthesia occurs within 2–10 minutes.a

Duration

Following topical application of a 0.5 or 1% solution of dyclonine, anesthesia persists for approximately 30 minutes.a

Stability

Storage

Oral

Lozenges

Protect from excessive heat (temperatures >38°C).100 a

Actions

  • Local anesthetic and analgesic.100 a b

Advice to Patients

  • Advise patients to suck rather than chew or bite the lozenge.100 a b

  • Advise patients to consult a clinician prior to use for a chronic cough secondary to smoking, asthma, or emphysema or a cough accompanied by excessive phlegm.100 b

  • Advise patients to discontinue the drug and consult a clinician if sore throat symptoms or cough do not improve after 2 days or if sore mouth symptoms do not improve after 7 days.100 b

  • If irritation, pain, or hypersensitivity occurs, discontinue use and consult a clinician or dentist.100 a b

  • Importance of informing clinician of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as any concomitant illnesses.100 b

  • Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.100 b

  • Importance of informing patients of other important precautionary information.100 b (See Cautions.)

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Dyclonine Hydrochloride

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Oral

Lozenges

1.2 mg*

Sucrets Children’s

Insight

2 mg*

Sucrets Regular Strength

Insight

3 mg*

Sucrets Maximum Strength

Insight

Dyclonine Hydrochloride Combinations

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Oral

Lozenges

3 mg with Menthol 6 mg

Sucrets Complete

Insight

AHFS DI Essentials. © Copyright, 2004-2014, Selected Revisions February 1, 2008. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.

References

100. Insight Pharmaceuticals. Sucrets Complete Lozenge patient information. Langhorne, PA; Undated.

a. AHFS drug information 2007. McEvoy GK, ed. Dyclonine. Bethesda, MD: American Society of Health-System Pharmacists; 2007: pages 2846-7.

b. Insight Pharmaceuticals. Sucrets Lozenge patient information. Langhorne, PA; Undated.

More about dyclonine topical

Consumer resources

Related treatment guides

Hide
(web4)