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Iressa

Generic Name: gefitinib (ge FI ti nib)
Brand Names: Iressa

What is Iressa?

Iressa (gefitinib) is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Iressa is used in to treat non-small cell lung cancer. Gefitinib is usually given after other cancer medicines have been tried without success.

Iressa may also be used for purposes not listed in this medication guide.

Important information

Iressa should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

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Serious side effects have been reported with the use of Iressa including: allergic reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); lung problems; liver problems; eye problems; severe nausea, vomiting, loss of appetite, or diarrhea; and others. Talk to your doctor about the possible side effects from treatment with Iressa.

Before taking this medicine

You should not use Iressa if you are allergic to gefitinib.

To make sure Iressa is safe for you, tell your doctor if you have:

  • liver disease;

  • kidney disease;

  • breathing problems, lung disease other than lung cancer; or

  • if you take a blood thinner (warfarin, Coumadin, Jantoven).

FDA pregnancy category D. Do not use Iressa if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

See also: Pregnancy and breastfeeding warnings (in more detail)

It is not known whether gefitinib passes into breast milk or if it could harm a nursing baby. Do not breast-feed while taking Iressa.

How should I use Iressa?

Iressa should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agent. Follow all directions on the prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You may take Iressa with or without food.

To make swallowing easier:

  • Place the tablet into a glass of water (4 ounces) and allow the tablet to disperse in the water for about 10 minutes. The tablet will not dissolve completely.

  • Do not use any liquid other than water.

  • Stir and drink this mixture right away. Do not save for later use.

  • To make sure you get the entire dose, add a little more liquid to the same glass, swirl gently and drink right away.

  • This mixture can also be given through a nasogastric (NG) tube. Ask your healthcare provider for instructions.

While using Iressa, you may need frequent blood tests to check your liver function.

Store at room temperature away from moisture and heat.

Iressa dosing information

Usual Adult Dose for Non-Small Cell Lung Cancer:

250 mg orally with or without food

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Iressa?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Iressa side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Iressa: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • sudden chest pain or discomfort, wheezing, dry cough, feeling short of breath;

  • fever, tired feeling, loss of appetite, weight loss;

  • eye discomfort or irritation;

  • severe or ongoing diarrhea, nausea, vomiting;

  • severe pain in your upper stomach spreading to your back; or

  • unusual bleeding (nosebleeds, blood in your urine).

Common Iressa side effects may include:

  • nausea, vomiting, diarrhea;

  • acne;

  • dry skin; or

  • itching or skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Iressa?

Other drugs may interact with gefitinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about Iressa.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Iressa only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 3.01. Revision Date: 2014-05-15, 9:16:04 AM.

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