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Drug Interaction Report

3 potential interactions and/or warnings found for the following 2 drugs:

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Interactions between your drugs

Major

calcium carbonate patiromer

Applies to: Calci-Chew (calcium carbonate), patiromer

Calcium carbonate may reduce the effectiveness of patiromer in binding potassium. In addition, combining these medications may increase the risk of developing metabolic alkalosis, which is a pH imbalance in the body caused by accumulation of an alkaline substance such as bicarbonate. It may be more likely to occur if you have severe kidney impairment. Symptoms of metabolic alkalosis may include nausea, vomiting, lightheadedness, tremor, muscle twitching, numbness or tingling, prolonged muscle spasms, slowed breathing, irregular heartbeat, confusion, and stupor. Severe cases may lead to seizure and coma. Do not take any over-the-counter antacids or laxatives without consulting with a healthcare professional first. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

calcium carbonate food

Applies to: Calci-Chew (calcium carbonate)

Calcium absorption may be increased by taking it with food. However, foods high in oxalic acid (spinach or rhubarb), or phytic acid (bran and whole grains) may decrease calcium absorption. Calcium may be taken with food to increase absorption. Consider spacing calcium administration for at least 2 hours before or after consuming foods high in oxalic acid or phytic acid. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

patiromer food

Applies to: patiromer

Patiromer may bind to many different oral medications in the gastrointestinal tract and reduce their absorption into the blood stream. The effectiveness of some oral medications may be decreased when taken with patiromer. To minimize the possibility of interaction, it is recommended that you separate the dosing times of patiromer and any oral medication you take by at least three hours. Talk to your doctor if you are unable to do so or if you have other questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No duplication warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.