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Drug Interaction Report

3 potential interactions and/or warnings found for the following 2 drugs:

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Interactions between your drugs

Moderate

ranolazine afatinib

Applies to: ranolazine, afatinib

Ranolazine may increase the blood levels of afatinib. You may be more likely to experience side effects such as mouth sores; diarrhea, which can lead to dehydration and kidney problems if severe; skin reactions such as dryness, redness, rash, acne, peeling, or blistering; lung disorders causing breathing difficulty, shortness of breath, cough, and fever; eye problems resulting in eye pain, swelling, redness, tearing, light sensitivity, blurred vision, and other vision disturbances; liver damage indicated by symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes; and heart problems resulting in tiredness, shortness of breath (either at rest or during activities), palpitation, water retention, sudden weight gain, and swelling of the feet, ankles, or legs. Contact your doctor immediately if you develop these or other unusual symptoms. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Major

ranolazine food

Applies to: ranolazine

You may take ranolazine with or without food, but should try to take it the same way every time. Grapefruit and grapefruit juice should be avoided if possible. Grapefruit juice can increase the levels of ranolazine in your body. High blood levels of food can occasionally cause an irregular heart rhythm that may be serious. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats during treatment with ranolazine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

afatinib food

Applies to: afatinib

Food may reduce the absorption of afatinib, which may lead to lower blood levels of the medication and possibly reduced effectiveness. You should take afatinib at least 1 hour before or 2 hours after a meal.

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Therapeutic duplication warnings

No duplication warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.