Drug Interaction Report
8 potential interactions and/or warnings found for the following 2 drugs:
- Aloprim (allopurinol)
- aspirin / caffeine / orphenadrine
Interactions between your drugs
allopurinol orphenadrine
Applies to: Aloprim (allopurinol), aspirin / caffeine / orphenadrine
Consumer information for this interaction is not currently available.
MONITOR: Coadministration with alcohol or other central nervous system (CNS) depressants may enhance the sedative effects of allopurinol and increase the likelihood and/or severity of central nervous system (CNS) side effects, such as drowsiness, somnolence, vertigo, and ataxia.
MANAGEMENT: Caution for increased CNS adverse effects is advised if allopurinol is coadministered with alcohol, other CNS depressants, or agents that cause dizziness or vertigo. Patients should not drive, operate machinery, or engage in hazardous activities requiring mental alertness and motor coordination until they know how the medications affect them.
allopurinol aspirin
Applies to: Aloprim (allopurinol), aspirin / caffeine / orphenadrine
Information for this minor interaction is available on the professional version.
aspirin caffeine
Applies to: aspirin / caffeine / orphenadrine, aspirin / caffeine / orphenadrine
Information for this minor interaction is available on the professional version.
Drug and food interactions
allopurinol food
Applies to: Aloprim (allopurinol)
Consumer information for this interaction is not currently available.
ADJUST DOSING INTERVAL: The tolerability of allopurinol may be improved by giving it after a meal. Additionally, when the dose is greater than 300 mg, dividing the total daily dose into smaller doses administered more often may be appropriate to help minimize gastrointestinal irritation.
MONITOR: Concomitant use of allopurinol with central nervous system (CNS) depressants, including alcohol, may potentiate adverse effects such as somnolence and sedation.
MANAGEMENT: To improve tolerability, some manufacturers suggest administering allopurinol after a meal. Additionally, if the daily dose is greater than 300 mg, administering allopurinol in divided doses may help reduce gastrointestinal intolerance. Patients should also be counseled to avoid or limit consumption of alcohol and to avoid activities requiring mental alertness such as driving or operating hazardous machinery until they know how the medication affects them.
orphenadrine food
Applies to: aspirin / caffeine / orphenadrine
Alcohol can increase the nervous system side effects of orphenadrine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with orphenadrine. Do not use more than the recommended dose of orphenadrine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
aspirin food
Applies to: aspirin / caffeine / orphenadrine
Ask your doctor before using aspirin together with ethanol. Do not drink alcohol while taking aspirin. Alcohol can increase your risk of stomach bleeding caused by aspirin. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
caffeine food
Applies to: aspirin / caffeine / orphenadrine
Information for this minor interaction is available on the professional version.
aspirin food
Applies to: aspirin / caffeine / orphenadrine
Information for this minor interaction is available on the professional version.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Further information
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