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Drug Interaction Report

12 potential interactions and/or warnings found for the following 4 drugs:

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Interactions between your drugs

Moderate

albuterol salmeterol

Applies to: Ventolin (albuterol), fluticasone / salmeterol

Using albuterol together with salmeterol may increase cardiovascular side effects such as elevations in heart rate and blood pressure or irregular heart rhythm. Talk to your doctor if you have any questions or concerns, particularly if you have a history of high blood pressure, arrhythmia, or heart disease. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

albuterol rasagiline

Applies to: Ventolin (albuterol), Azilect (rasagiline)

Using albuterol together with rasagiline may increase cardiovascular side effects such as heart palpitations, chest pain, increased heart and pulse rates, and blood pressure elevations. The risk exists even when albuterol or similar medications are given by oral inhalation directly into the lungs, and more so if these products are overused. Talk to your doctor before using these medications if you have a history of heart disease or high blood pressure. Depending on your condition, it may be preferable to wait at least 14 days after you are off rasagiline before you start using albuterol. Do not exceed the dose and frequency of use of albuterol recommended on the product label or prescribed by your doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

salmeterol rasagiline

Applies to: fluticasone / salmeterol, Azilect (rasagiline)

Using salmeterol together with rasagiline may increase cardiovascular side effects such as heart palpitations, chest pain, increased heart and pulse rates, and blood pressure elevations. The risk exists even when salmeterol or similar medications are given by oral inhalation directly into the lungs, and more so if these products are overused. Talk to your doctor before using these medications if you have a history of heart disease or high blood pressure. Depending on your condition, it may be preferable to wait at least 14 days after you are off rasagiline before you start using salmeterol. Do not exceed the dose and frequency of use of salmeterol recommended on the product label or prescribed by your doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Minor

albuterol fluticasone

Applies to: Ventolin (albuterol), fluticasone / salmeterol

Information for this minor interaction is available on the professional version.

Minor

albuterol budesonide

Applies to: Ventolin (albuterol), Pulmicort Turbuhaler (budesonide)

Information for this minor interaction is available on the professional version.

Minor

fluticasone salmeterol

Applies to: fluticasone / salmeterol, fluticasone / salmeterol

Information for this minor interaction is available on the professional version.

Minor

salmeterol budesonide

Applies to: fluticasone / salmeterol, Pulmicort Turbuhaler (budesonide)

Information for this minor interaction is available on the professional version.

No other interactions were found between your selected drugs. However, this does not necessarily mean no other interactions exist. Always consult your healthcare provider.

Drug and food interactions

Moderate

budesonide food

Applies to: Pulmicort Turbuhaler (budesonide)

You should avoid the regular consumption of large amounts of grapefruits and grapefruit juice while taking budesonide. Grapefruit can raise the levels of budesonide in your body and lead to increased side effects. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

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Moderate

rasagiline food

Applies to: Azilect (rasagiline)

Rasagiline may be taken with or without food. There is no need to avoid most foods and beverages during treatment with rasagiline, as long as you are not receiving more than 1 mg per day of the medication. However, certain foods such as some of the aged cheeses (for example, Boursault, Liederkrantz, Mycella, and Stilton) may contain very high amounts of tyramine and should generally be avoided if possible. Consumption of very high levels of tyramine (greater than 150 mg) while on rasagiline treatment may lead to dangerous increases in your blood pressure, a condition known as hypertensive crisis. Talk to your doctor or pharmacist if you are uncertain about what foods, if any, to avoid. You should seek immediate medical attention if you experience sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting during treatment with rasagiline, as these may be signs and symptoms of a hypertensive crisis. It is important to tell your doctor about all other medications you use, including vitamins and herbs, since some medications may increase the blood levels of rasagiline and possibly lead to interactions with tyramine-rich foods. Do not stop using any medications without first talking to your doctor.

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Moderate

albuterol food

Applies to: Ventolin (albuterol)

Both albuterol and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Cortisones

Therapeutic duplication

The recommended maximum number of medicines in the 'cortisones' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'cortisones' category:

  • fluticasone / salmeterol
  • Pulmicort Turbuhaler (budesonide)

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

Duplication

Inhaled smooth muscle relaxants

Therapeutic duplication

The recommended maximum number of medicines in the 'inhaled smooth muscle relaxants' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'inhaled smooth muscle relaxants' category:

  • fluticasone / salmeterol
  • Ventolin (albuterol)

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.