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Trisodium Citrate Dihydrate

Excipient (pharmacologically inactive substance)

What is it?

Trisodium citrate dihydrate (C6H5Na3O7.2H2O) is a tribasic salt of citric acid. It has a sour taste similar to citric acid, and is salty as well. It is often used as a food preservative, and as a flavoring in the food industry. In the pharmaceutical industry it is used to control pH. It may be used as an alkalizing agent, buffering agent, emulsifier, or sequestering agent.[1]

According to the FDA Select Committee on Generally Recognized as Safe (GRAS) food substances, citrate salts, including sodium citrate, are generally regarded as safe when used in normal quantities.[2]

[1] Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 Accessed 08/19/2011

[2] FDA’s SCOGS database; triethyl citrate; SCOGS-Report Number: 84; Accessed March 26, 2012.

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