Trisodium Citrate Dihydrate
Excipient (pharmacologically inactive substance)
What is Trisodium Citrate Dihydrate?
Trisodium citrate dihydrate (C6H5Na3O7.2H2O) is a tribasic salt of citric acid. It has a sour taste similar to citric acid, and is salty as well. It is often used as a food preservative, and as a flavoring in the food industry. In the pharmaceutical industry it is used to control pH. It may be used as an alkalizing agent, buffering agent, emulsifier, or sequestering agent.[1]
According to the FDA Select Committee on Generally Recognized as Safe (GRAS) food substances, citrate salts, including sodium citrate, are generally regarded as safe when used in normal quantities.[2]
[1] Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
[2] FDA’s SCOGS database; triethyl citrate; SCOGS-Report Number: 84; http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=scogsListing&id=356 Accessed March 26, 2012.
Top Medications Containing Trisodium Citrate Dihydrate
- Didanosine Delayed Release 200 mg (Mylan Pharmaceuticals Inc.)
- Didanosine Delayed Release 125 mg (Mylan Pharmaceuticals Inc.)
- Didanosine Delayed Release 400 mg (Mylan Pharmaceuticals Inc.)
- Didanosine Delayed Release 250 mg (Mylan Pharmaceuticals Inc.)
- Meloxicam 15 mg (Aurobindo Pharma)
- Meloxicam 7.5 mg (Aurobindo Pharma)
- Meloxicam 15 mg (Teva Pharmaceuticals USA)
- Meloxicam 7.5 mg (Glenmark Generics Inc.)
- Meloxicam 7.5 mg (Teva Pharmaceuticals USA)
- Meloxicam 15 mg (Glenmark Generics Inc.)
- Mobic 15 mg (Boehringer Ingelheim Pharmaceuticals, Inc.)
- Mobic 7.5 mg (Boehringer Ingelheim Pharmaceuticals, Inc.)
