Povidone K25
Excipient (pharmacologically inactive substance)
What is Povidone K25?
Povidone (polyvinylpyrrolidone, PVP) is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs. It has multiple uses, including as a binder for tablets and capsules, a film former for ophthalmic solutions, to aid in flavoring liquids and chewable tablets, and as an adhesive for transdermal systems.[1]
Povidone has the molecular formula of (C6H9NO)n and appears as a white to slightly off-white powder. Povidone formulations are widely used in the pharmaceutical industry due to their ability to dissolve in both water and oil solvents. The k number refers to the mean molecular weight of the povidone. Povidones with higher K-values (i.e., k90) are not usually given by injection due to their high molecular weights. The higher molecular weights prevent excretion by the kidneys and lead to accumulation in the body. The best-known example of povidone formulations is povidone-iodine, an important disinfectant.[2]
[1] Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
[2] Folttman H, Quadir A. Excipent Update. Polyvinylpyrrolidone (PVP) - one of the mosy widely used excipients in pharmaceuricals: an overview. Drug Delivery Technology. Vol 8;6:22-7. Accessed April 9, 2012. http://www.pharma-ingredients.basf.com/Documents/ENP/Review%20Articles/DDT-June-2008.pdf
Top Medications Containing Povidone K25
- Angeliq drospirenone 0.5 mg / estradiol 1 mg (Berlex Laboratories)
- Lamotrigine (Chewable, Dispersible) 25 mg (Glenmark Generics Inc.)
- Meloxicam 15 mg (Aurobindo Pharma)
- Meloxicam 7.5 mg (Aurobindo Pharma)
- Natazia estradiol valerate 3 mg (Bayer HealthCare Pharmaceuticals Inc.)
- Natazia estradiol valerate 3 mg (Bayer HealthCare Pharmaceuticals Inc.)
- Natazia estradiol valerate 3 mg (Bayer HealthCare Pharmaceuticals Inc.)
- Natazia estradiol valerate 3 mg (Bayer HealthCare Pharmaceuticals Inc.)
- Ocella drospirenone 3 mg / ethinyl estradiol 0.03 mg (Teva Pharmaceuticals USA)
- Ocella drospirenone 3 mg / ethinyl estradiol 0.03 mg (Teva Pharmaceuticals USA)
- Pantoprazole Sodium Delayed Release 40 mg (ESI Lederle Generics)
- Pantoprazole Sodium Delayed Release 20 mg (Wyeth Pharmaceuticals)
- Protonix 40 mg (Wyeth)
- Protonix 20 mg (Wyeth-Ayerst Laboratories)
- Sutent 25 mg (Pfizer U.S. Pharmaceuticals Group)
- Sutent 50 mg (Pfizer U.S. Pharmaceuticals Group)
- Sutent 12.5 mg (Pfizer U.S. Pharmaceuticals Group)
- Yasmin inert (Berlex Laboratories)
- Yasmin inert (Berlex Laboratories)
- Yaz drospirenone 3 mg / ethinyl estradiol 0.02 mg (Berlex Laboratories)
