Citric Acid Anhydrous
Excipient (pharmacologically inactive substance)
What is Citric Acid Anhydrous?
Citric acid is a weak organic acid commonly used in the food, cosmetic and pharmaceutical industry. The parent base of citric acid, citrate, is a component of the Krebs cycle, and occurs naturally during metabolism in all living organisms. It is found naturally in citrus fruit such as lemons and limes and is used as a natural preservative. Anhydrous citric acid has had the water molecules removed and is usually in a dry, powdered formulation.[1][2]
Citrate or citric acid is often used to adjust pH, to add sour flavor to foods and beverages, and to form the salt derivative of minerals and metals for pharmaceuticals, as in the case of potassium citrate, a dietary supplement. According to the FDA Select Committee on Generally Recognized as Safe (GRAS) food substances, citrate salts, including citric acid, are generally regarded as safe when used in normal quantities.[2]
[1] Anastassiadis S, Morgunov IG, Kamzolova SV, et al. Citric acid production patent review. Recent Patent Biotechnol. 2008;2:107-23. http://www.ncbi.nlm.nih.gov/pubmed/19075859
[2] FDA’s SCOGS database; triethyl citrate; SCOGS-Report Number: 84; http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=scogsListing&id=356 Accessed March 26, 2012.
Top Medications Containing Citric Acid Anhydrous
- Atenolol 50 mg (Zydus Pharmaceuticals USA Inc.)
- Buprenorphine Hydrochloride (Sublingual) 8 mg (Roxane Laboratories, Inc.)
- Buprenorphine Hydrochloride (Sublingual) 8 mg (Teva Pharmaceuticals USA)
- Buprenorphine Hydrochloride (Sublingual) 8 mg (Ethypharm S.A.)
- Buprenorphine Hydrochloride (Sublingual) 2 mg (Teva Pharmaceuticals USA)
- Buprenorphine Hydrochloride (Sublingual) 2 mg (Roxane Laboratories, Inc.)
- Clarithromycin Extended Release 500 mg (Teva Pharmaceuticals USA)
- Naprelan 500 naproxen sodium 550 mg (equiv. naproxen 500 mg) (Victory Pharma)
- Naprelan 750 naproxen sodium 825 mg (equiv. naproxen 750 mg) (Victory Pharma)
- Simvastatin 40 mg (Dr. Reddy’s Laboratories Inc.)
- Simvastatin 20 mg (Zydus Pharmaceuticals)
- Simvastatin 40 mg (Zydus Pharmaceuticals)
- Simvastatin 20 mg (Dr. Reddy’s Laboratories Inc.)
- Simvastatin 10 mg (Zydus Pharmaceuticals)
- Simvastatin 80 mg (Zydus Pharmaceuticals)
- Simvastatin 10 mg (Dr. Reddy’s Laboratories Inc.)
- Suboxone 8 mg / 2 mg (Reckitt Benckiser Pharmaceuticals, Inc.)
- Suboxone 2 mg / 0.5 mg (Reckitt Benckiser Pharmaceuticals, Inc.)
- Subutex 8 mg (Reckitt Benckiser Pharmaceuticals, Inc.)
- Subutex 2 mg (Reckitt Benckiser Pharmaceuticals, Inc.)
