I have an 18 year history of well controlled depression. Before Christmas, my Psychiatrist changed my medication from Zoloft to Wellbutrin. I asked him to do this because I just think that I could feel better than I had been. I was doing great on the Wellbutrin, no problems and then 10 days ago I developed a sinus infection for which I was given prednisone. I took 1 40 mg dose and had BAD side effects. My Dr. told me to quit taking it. The next day I was in the ER with nausea/vomitting and dehydration. I was given 8 mg of Zofran and 2 liters of fluids. I was also sent home with Zofran ODT. I was starting to feel normal again when out of the blue, I had an anxiety attack, and all of those feelings of being out of control again resurfaced. I am now having trouble staying asleep, being anxious about "is my depression/anxiety returning", being fearful of being alone, etc. HELP! I am trying to tell myself that it is just all from being sick, fatigued, etc. I need some peace of mind. I am going to try and get in with my Psychiatrist tomorrow.