Luckily not as scary and as serious as what happened to you. But I took
Benadryl last night. I currently take 100mg of
Lamictal daily and 25mg of
Paxil. I had really bad allergies last night and took 2 Benadryl (50mg). I could not get out of bed. And I could barely move. When I did get up I tried driving to work but failed miserably and decided to turn back before I had an accident.
I called my doctor and he explained that the two drugs might have had an interaction and Lamictal may have caused the levels of Benadryl to rise in my blood. I'm still pretty lethargic and it's been over 12 hours since I took the Benadryl.
Both drugs seem to be histamine antagonists. This means that they bind to the histamine receptors in your brain and cause a sedating effect. Because Lamictal binds to the histamine receptors, it does not let Benadryl bind and so the levels of Benadryl in your blood become higher than they should, resulting in a severe sedative effect. When I googled lamictal + benadryl I stumbled upon your post and a post on another site of a person that uses the combo recreationally!
My recommendation to you is to stay away from Benadryl!