Seldane (terfenadine) Alcohol, Food & Lifestyle Interactions
There is 1 food and lifestyle interaction with Seldane (terfenadine):
Major Food Interaction
CONTRAINDICATED: The consumption of grapefruit juice has been associated with significantly increased plasma concentrations of terfenadine. The mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall induced by certain compounds present in grapefruits. Terfenadine in high serum levels has been associated with prolongation of the QT interval and development of torsade de pointes, a potentially fatal ventricular arrhythmia.
MANAGEMENT: Due to the risk of cardiotoxicity, patients receiving the drug should be advised to avoid consumption of grapefruit products. Loratadine, cetirizine, and fexofenadine may be safer alternatives in patients who may have trouble adhering to the dietary restriction.
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Seldane (terfenadine) drug Interactions
There are 225 drug interactions with Seldane (terfenadine)
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