Tegretol (carbamazepine) Alcohol, Food & Lifestyle Interactions

There are 2 food and lifestyle interactions with Tegretol (carbamazepine) which include:

GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and impairment of judgment, thinking, and psychomotor skills.

MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

GENERALLY AVOID: In a small, randomized, crossover study, the administration of carbamazepine with grapefruit juice (compared to water) increased plasma drug concentrations by approximately 40%. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits.

MANAGEMENT: Given the drug's narrow therapeutic index, patients receiving carbamazepine therapy should preferably avoid the regular consumption of grapefruits and grapefruit juice to prevent any undue fluctuations in plasma drug levels. Patients should be advised to report signs of carbamazepine toxicity (nausea, visual disturbances, dizziness, or ataxia) to their physicians.

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Tegretol (carbamazepine) drug Interactions

There are 840 drug interactions with Tegretol (carbamazepine)

Tegretol (carbamazepine) disease Interactions

There are 6 disease interactions with Tegretol (carbamazepine) which include:

Blood Dyscrasias Cardiovascular Disease Liver Disease

Anticholinergic Effects Psychosis Thyroid Function Tests

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