Exforge HCT (amlodipine/hydrochlorothiazide/valsartan) and Alcohol / Food Interactions

There are 5 alcohol/food/lifestyle interactions with Exforge HCT (amlodipine/hydrochlorothiazide/valsartan) which include:

MONITOR: Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants) exhibit hypotensive effects, especially during initiation of therapy and dose escalation. Coadministration with antihypertensive agents, in particular vasodilators and alpha-blockers, may result in additive effects on blood pressure and orthostasis.

MANAGEMENT: Caution is advised during coadministration of these agents. Close monitoring for development of hypotension is recommended. Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia.

The antihypertensive effect of amlodipine and thiazide diuretics may be additive. Management consists of monitoring blood pressure during coadministration, especially during the first 1 to 3 weeks of therapy.

MONITOR: Calcium-containing products may decrease the effectiveness of calcium channel blockers by saturating calcium channels with calcium. Calcium chloride has been used to manage acute severe verapamil toxicity.

MANAGEMENT: Management consists of monitoring the effectiveness of calcium channel blocker therapy during coadministration with calcium products.

The antihypertensive effect of amlodipine and thiazide diuretics may be additive. Management consists of monitoring blood pressure during coadministration, especially during the first 1 to 3 weeks of therapy.

GENERALLY AVOID: Moderate-to-high dietary intake of potassium, especially salt substitutes, may increase the risk of hyperkalemia in some patients who are using angiotensin II receptor blockers (ARBs). ARBs can promote hyperkalemia through inhibition of angiotensin II-induced aldosterone secretion. Patients with diabetes, heart failure, dehydration, or renal insufficiency have a greater risk of developing hyperkalemia.

MANAGEMENT: Patients should receive dietary counseling and be advised to not use potassium-containing salt substitutes or over-the-counter potassium supplements without consulting their physician. If salt substitutes are used concurrently, regular monitoring of serum potassium levels is recommended. Patients should also be advised to seek medical attention if they experience symptoms of hyperkalemia such as weakness, irregular heartbeat, confusion, tingling of the extremities, or feelings of heaviness in the legs.

The consumption of grapefruit juice may slightly increase plasma concentrations of amlodipine. The mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. Data have been conflicting and the clinical significance is unknown. Monitoring for calcium channel blocker adverse effects (e.g., headache, hypotension, syncope, tachycardia, edema) is recommended.

thiazides - hyperlipidemia

Thiazide diuretics may increase serum triglyceride and cholesterol levels, primarily LDL and VLDL. Whether these effects are dose-related and sustained during chronic therapy are unknown. Patients with preexisting hyperlipidemia may require closer monitoring during thiazide therapy, and adjustments made accordingly in their lipid-lowering regimen

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Exforge HCT (amlodipine/hydrochlorothiazide/valsartan) drug Interactions

There are 796 drug interactions with Exforge HCT (amlodipine/hydrochlorothiazide/valsartan)

Exforge HCT (amlodipine/hydrochlorothiazide/valsartan) disease Interactions

There are 18 disease interactions with Exforge HCT (amlodipine/hydrochlorothiazide/valsartan) which include:

Hypotension Cardiogenic Shock/Hypotension Coronary Artery Disease Liver Disease Anuria Electrolyte Losses Liver Disease Lupus Erythematosus Renal Function Disorders

Chf Renal Artery Stenosis Chf/Ami Diabetes Hyperlipidemia Hyperparathyroidism Hyperuricemia Thyroid Function Tests Renal/Liver Disease

See also...

• Exforge HCT (amlodipine/hydrochlorothiazide/valsartan) Side Effects
• Exforge HCT (amlodipine/hydrochlorothiazide/valsartan) Consumer Information

• Drug Interactions Checker

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