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Drug Interactions between vorapaxar and Xtandi

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

enzalutamide vorapaxar

Applies to: Xtandi (enzalutamide) and vorapaxar

GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may decrease the plasma concentrations of vorapaxar, which is a substrate of the isoenzyme. When vorapaxar was coadministered with rifampin 600 mg, mean vorapaxar peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by approximately 35% and 50%, respectively.

MANAGEMENT: Concomitant use of vorapaxar with potent CYP450 3A4 inducers should generally be avoided due to the potential for reduced efficacy.

References

  1. (2014) "Product Information. Zontivity (vorapaxar)." Merck & Co., Inc

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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