Drug Interactions between tucatinib and Xaracoll
This report displays the potential drug interactions for the following 2 drugs:
- tucatinib
- Xaracoll (bupivacaine)
Interactions between your drugs
BUPivacaine tucatinib
Applies to: Xaracoll (bupivacaine) and tucatinib
GENERALLY AVOID: Coadministration with tucatinib may increase the plasma concentrations of CYP450 3A4 substrates. The mechanism involves tucatinib-mediated inhibition of CYP450 3A isoenzymes. When a single 2 mg dose of midazolam, a CYP450 3A substrate, was administered with tucatinib (300 mg twice daily), midazolam peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 3-fold and 5.7-fold, respectively. Increased exposure to the CYP450 3A substrate may increase the risk of toxicity.
MANAGEMENT: Concomitant use of tucatinib with CYP450 3A substrates, particularly those with a narrow therapeutic index, should be avoided. If coadministration is required, a reduction in the dosage of the CYP450 3A substrate in accordance with product labeling is recommended.
References
- (2020) "Product Information. Tukysa (tucatinib)." Seattle Genetics Inc
Drug and food interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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